Publications by authors named "R J Beynon"
Article Synopsis
- The study explores the link between hip shape and the risk of hip osteoarthritis and fractures, using data from large cohorts to analyze genetic factors influencing hip shape.
- Researchers identified numerous genetic signals related to hip shape but found no causal effect of hip shape on osteoarthritis, while certain hip shapes were linked to a higher risk of hip fractures.
- The findings suggest that focusing on hip shape might not be an effective strategy for preventing osteoarthritis in older adults, despite its association with hip fractures.
Article Synopsis
- Hypertrophic cardiomyopathy (HCM) is a diverse heart condition that can lead to severe health issues and traditionally managed through symptom relief and the use of defibrillators to prevent sudden cardiac death.
- There is a recognized need for treatments that modify the disease itself, and recently, new therapies like mavacamten, a myosin inhibitor, have gained regulatory approval.
- Clinical trials for HCM face unique challenges, which include selecting patients based on their genetic and symptom profiles, measuring outcomes effectively, and considering factors like trial duration and sample size when interpreting results.
Sex differences in the radiographic and symptomatic prevalence of knee and hip osteoarthritis.
Front Endocrinol (Lausanne)
October 2024
Recognising sex differences in disease prevalence can lead to clues as to its pathogenesis, for example the role of hormonal factors and related influences such as body composition, as well as forming the basis for new treatments. However, if different methods are used to define the disorder it can be difficult to explore differences in prevalence, making it necessary to draw on multiple sources of evidence. This narrative review addresses sex differences in the prevalence of knee and hip osteoarthritis, which are the most common forms of large joint osteoarthritis.
View Article and Find Full Text PDFBackground: Pharmacogenetic guided prescribing can be used to improve the safety and effectiveness of medicines. There are several approaches by which this intervention might be implemented in clinical practice, which will vary depending on the health system and clinical context.
Aim: To understand the clinical utility of panel-based pharmacogenetic testing in patients admitted acutely to hospital and to establish variables which predict if an individual might benefit from the intervention.
Protein kinase A (PKA) is a conserved kinase crucial for fundamental biological processes linked to growth, development, and metabolism. The PKA catalytic subunit is expressed as multiple isoforms in diverse eukaryotes; however, their contribution to ensuring signaling specificity in response to environmental cues remains poorly defined. Catalytic subunit activity is classically moderated via interaction with an inhibitory regulatory subunit.
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