Publications by authors named "R J Berni"
HCV infection poses a global health threat, with significant morbidity and mortality. This study examines HCV trends in a large Italian region from 2015 to 2022, considering demographic changes, evolving clinical profiles, treatment regimens and outcomes, including the impact of the COVID-19 pandemic. This multicentre retrospective study analysed demographics, clinical histories and risk factors in 6882 HCV patients.
View Article and Find Full Text PDFTransthyretin (TTR) is an amyloidogenic homotetramer involved in the transport of thyroxine in blood and cerebrospinal fluid. To date, more than 130 TTR point mutations are known to destabilise the TTR tetramer, leading to its extracellular pathological aggregation accumulating in several organs, such as heart, peripheral and autonomic nerves, and leptomeninges. Tolcapone is an FDA-approved drug for Parkinson's disease that has been repurposed as a TTR stabiliser.
View Article and Find Full Text PDFClimate change results in exceptional environmental conditions and drives the migration of pathogens to which local plants are not adapted. Biotic stress disrupts plants' metabolism, fitness, and performance, ultimately impacting their productivity. It is therefore necessary to develop strategies for improving plant resistance by promoting stress responsiveness and resilience in an environmentally friendly and sustainable way.
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- Apple russeting is caused by suberin accumulation in response to cuticle damage, and research is ongoing to understand the regulatory mechanisms behind this process, particularly focusing on MYB transcription factors.* -
- The study validated the function of the MdMYB68 transcription factor through experiments in Nicotiana benthamiana, including RNA-Seq and lipid quantification, revealing that it triggers the entire suberin biosynthesis pathway.* -
- Findings indicate that MdMYB68 not only boosts suberin deposition but also significantly alters carbohydrate components in the cell wall, suggesting its role in regulating both aliphatic and aromatic suberin deposition in apple fruit.*
Brodifacoum is the most common rodenticide used for the eradication of invasive rodents from islands. It blocks the vitamin K cycle, resulting in hemorrhages in target mammals. Non-target species may be incidentally exposed to brodifacoum, including marine species.
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