Publications by authors named "R J Baber"
Article Synopsis
- * This review analyzed research on psychological and mind-body interventions to alleviate symptoms and improve quality of life for those in perimenopause and postmenopause stages, using various data sources.
- * The findings support effective therapeutic options like cognitive behavioral therapy and yoga, advocating for a culturally responsive, multimodal online care model to ensure broader access and equity in menopause management.
Establishing a strategy for sequencing of T cell-redirecting therapies for relapsed/refractory multiple myeloma (RRMM) is a pressing clinical need. We longitudinally tracked the clinical and immunologic impact of bispecific T cell-engaging antibodies (BsAb) as bridging therapy (BT) to subsequent B-cell maturation antigen-directed chimeric antigen receptor T (CAR-T) cell therapies in 52 patients with RRMM. BsAbs were a potent and safe option for BT, achieving the highest overall response rate (100%) to BT compared with chemotherapy, anti-CD38, or anti-SLAMF7 antibody-based regimens (46%).
View Article and Find Full Text PDFBackground And Aims: Understanding molecular processes of the early phase of atherosclerotic cardiovascular disease conditions is of utmost importance for early prediction and intervention measures.
Methods: We measured 92 cardiovascular-disease-related proteins (Olink, Cardiovascular III) in 2024 elderly participants of the population-based LIFE-Adult study. We analysed the impact of 27 covariables on these proteins including blood counts, cardiovascular risk factors and life-style-related parameters.
Background: Physiological changes of blood amino acids and acylcarnitines during healthy child development are poorly studied. The LIFE (Leipziger Forschungszentrum für Zivilisationserkrankungen) Child study offers a platform with a large cohort of healthy children to investigate these dynamics. We aimed to assess the intra-person variability of 28 blood metabolites and their associations with anthropometric parameters related to growth and excess body fat.
View Article and Find Full Text PDFArticle Synopsis
- - Coagulation factor XII (FXII) is linked to thrombosis and inflammation and is found in increased levels in diabetes and diabetic kidney disease (DKD), but its specific role in DKD was unclear until now.
- - The study reveals that FXII is present in kidney tubular cells, correlating with kidney dysfunction in DKD patients; mice lacking FXII showed protection against kidney damage from high blood sugar.
- - FXII promotes cell damage through a signaling pathway involving uPAR and integrin β1, leading to oxidative stress and cell aging; blocking these pathways may provide new diagnostic and treatment options for DKD and similar diseases.