Publications by authors named "R J B Goudie"
The increasing availability of high-dimensional, longitudinal measures of gene expression can facilitate understanding of biological mechanisms, as required for precision medicine. Biological knowledge suggests that it may be best to describe complex diseases at the level of underlying pathways, which may interact with one another. We propose a Bayesian approach that allows for characterizing such correlation among different pathways through dependent Gaussian processes (DGP) and mapping the observed high-dimensional gene expression trajectories into unobserved low-dimensional pathway expression trajectories via Bayesian sparse factor analysis.
View Article and Find Full Text PDFBackground: Nosocomial infections are costly, and airborne transmission is increasingly recognized as important for spread. Air cleaning units (ACUs) may reduce transmission, but little research has focused on their effectiveness on open wards.
Aim: To assess whether ACUs reduce nosocomial severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), or other, infections on older adult inpatient wards.
Article Synopsis
- Vaccines for COVID-19 and influenza can help protect pregnant women from severe infections, but not enough are getting vaccinated.
- Data from England and Wales showed that only about 40% of eligible pregnant women received at least one dose of these vaccines.
- There are significant disparities in vaccination rates, with lower uptake among socioeconomically disadvantaged and ethnic minority groups, highlighting the need for targeted interventions to improve vaccine acceptance.
Interim 2023/2024 Season Influenza Vaccine Effectiveness in Primary and Secondary Care in the United Kingdom.
Influenza Other Respir Viruses
May 2024
Background: We report 2023/2024 season interim influenza vaccine effectiveness for three studies, namely, primary care in Great Britain, hospital settings in Scotland and hospital settings in England.
Methods: A test negative design was used to estimate vaccine effectiveness.
Results: Estimated vaccine effectiveness against all influenzas ranged from 63% (95% confidence interval 46 to 75%) to 65% (41 to 79%) among children aged 2-17, from 36% (20 to 49%) to 55% (43 to 65%) among adults 18-64 and from 40% (29 to 50%) to 55% (32 to 70%) among adults aged 65 and over.