Publications by authors named "R J B Driessen"
The introduction of wire-free microcirculatory resistance index from functional angiography (angio-IMR) promises swift detection of coronary microvascular dysfunction, however it has not been properly validated. We sought to validate angio-IMR against invasive IMR and PET derived microvascular resistance (MVR). Moreover, we studied if angio-IMR could aid in the detection of ischemia with non-obstructive coronary arteries (INOCA).
View Article and Find Full Text PDFMicrovascular resistance reserve in relation to total and vessel-specific atherosclerotic burden.
Eur Heart J Cardiovasc Imaging
November 2024
Aims: The relationship between coronary artery atherosclerosis and microvascular resistance remains unclear. This study aims to clarify the relationship between total atherosclerotic and vessel-specific atherosclerotic burden and microvascular resistance reserve (MRR).
Methods And Results: In this post-hoc analysis of the PACIFIC 1 trial, symptomatic patients without prior coronary artery disease (CAD) underwent [15O]H2O positron emission tomography, coronary computed tomography angiography (CCTA) and invasive fractional flow reserve (FFR).
Article Synopsis
- - The study evaluates the effectiveness of quantitative perfusion cardiac magnetic resonance (QP-CMR) imaging in detecting significant coronary artery disease (CAD) in patients with a history of CAD and new chest pain, comparing it with visual assessment of stress perfusion CMR and quantitative PET imaging.
- - Involving 145 patients with prior heart issues, the research found QP-CMR's sensitivity at 66%, which is lower than PET at 80%, but its specificity is on par with both v-CMR and PET at about 60-63%.
- - Overall, the study concludes that QP-CMR's diagnostic performance is similar to that of both other imaging methods for identifying hemodynamically significant CAD, defined by fractional
Cardiac symptomatology and coronary artery disease. A clinical conundrum.
J Cardiovasc Comput Tomogr
September 2024
Background: Fractional flow reserve (FFR) has emerged as the invasive gold standard for assessing vessel-specific ischemia. However, FFR measurements are influenced by the hydrostatic effect, which might adversely impact the assessment of ischemia.
Aims: This study aimed to investigate the impact of hydrostatic pressure on FFR measurements by correcting for the height and comparing FFR with [O]HO positron emission tomography (PET)-derived relative flow reserve (RFR).