Publications by authors named "R J Aiello"

Article Synopsis
  • Aicardi Goutières Syndrome (AGS) is a rare genetic disorder characterized by a range of systemic health issues and delayed diagnosis, prompting researchers to analyze longitudinal data from medical records to better understand its burden.* -
  • The study included 167 individuals with genetically confirmed AGS, compiling information on demographics, age of onset, and neurological complications; the most frequent genetic mutations associated with AGS were identified.* -
  • Results revealed that gastrointestinal issues were the earliest systemic complications, while neurological symptoms such as tone abnormalities and irritability were prevalent, usually manifesting in infancy.*
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Background: Autism commonly co-occurs with attention-deficit/hyperactivity disorder (ADHD), but less is known regarding how ADHD symptoms impact the early presentation of autism. This study examined early behavioral characteristics of a community sample of toddlers later identified with autism diagnosis, ADHD symptoms, combined autism and ADHD symptoms, or neither condition.

Methods: Participants were 506 toddlers who were part of a longitudinal study of children's behavioral development.

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Quantum interference is a central resource in many quantum-enhanced tasks, from computation to communication. While usually occurring between identical photons, it can also be enabled by performing projective measurements that render the photons indistinguishable, a process known as quantum erasing. Structured light forms another hallmark of photonics, achieved by manipulating the degrees of freedom of light, and enables a multitude of applications in both classical and quantum regimes.

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Objective: Metachromatic leukodystrophy (MLD) is a rare neurodegenerative disorder. Emerging therapies are most effective in the presymptomatic phase, and thus defining this window is critical. We hypothesize that early development delay may precede developmental plateau.

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Objective: Cognitive Disengagement Syndrome (CDS; previously called Sluggish Cognitive Tempo) refers to a constellation of cognitive and motor behaviors characterized by a predisposition toward mind wandering (cognitive subdomain) and slowed motor behavior (hypoactive). While there are a number of studies linking CDS traits to greater global impairment in children with attention-deficit/hyperactivity disorder (ADHD) and autistic children, there are few studies examining the prevalence and impact of CDS traits in autistic children with co-occurring ADHD (Autistic+ADHD). The current study explored CDS traits in autistic children with and without co-occurring ADHD, children with ADHD, and neurotypical children.

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