Publications by authors named "R J A Moakes"
Intra-articular glucocorticoid injections are effective in controlling inflammation and pain in arthritides but restricted by short duration of action and risk of joint degeneration. Controlled drug release using biocompatible hydrogels offers a unique solution, but limitations of in situ gelation restrict their application. Gellan sheared hydrogels (GSHs) retain the advantages of hydrogels, however their unique microstructures lend themselves to intra-articular application - capable of shear thinning under force but restructuring at rest to enhance residence.
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- Acetic acid shows potential as an alternative to antibiotics for treating burn wounds, but its effectiveness is limited by its poor material properties for retention and site specificity.
- In this study, acetic acid was used as both a gelling agent and an antimicrobial component in alginate fluid gels, with the microstructure depending on the concentration of acetic acid.
- The resulting fluid gels exhibited improved sprayability and long-lasting surface retention, while maintaining antimicrobial effectiveness against common pathogens.
Skin inflammation associated with chronic diseases involves a direct role of keratinocytes in its immunopathogenesis, triggering a cascade of immune responses. Despite this, highly targeted treatments remain elusive, highlighting the need for more specific therapeutic strategies. In this study, nanocapsules containing quinizarin (QZ/NC) were developed and evaluated in an in vitro model of keratinocyte-mediated inflammation, incorporating the action of photodynamic therapy (PDT) and analyzing permeation in a 3D skin model.
View Article and Find Full Text PDFThe use of granular matrices to support parts during the bioprinting process was first reported by Bhattacharjee et al. in 2015, and since then, several approaches have been developed for the preparation and use of supporting gel beds in 3D bioprinting. This paper describes a process to manufacture microgel suspensions using agarose (known as fluid gels), wherein particle formation is governed by the application of shear during gelation.
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