Publications by authors named "R Isnard"
Article Synopsis
- The study investigates heart failure (HF) hospitalization in France post-pandemic, focusing on incidence, prevalence, patient characteristics, management, and outcomes based on sex, age, and socio-economic status.
- Utilizing a comprehensive health care database, findings reveal a prevalence rate of 1.7% in France, with an overall decrease in acute HF decompensation incidence since 2012, particularly among men under 45.
- Despite improvements in management and a decline in one-year rehospitalization rates, one-year mortality rates remain high, especially among younger women and the most deprived areas.
Article Synopsis
- * A large study involving nearly 10,000 DCM cases and close to a million controls identified 70 significant genetic locations linked to the disease, revealing the importance of heart muscle cells in its development.
- * The research also indicates that factors like higher body weight and blood pressure may contribute to DCM, and genetic risk scores can help predict the condition across different populations.
Article Synopsis
- - In 2022, France recorded 181,178 hospitalizations for heart failure (HF), yielding a prevalence rate of 2.6% among adults, while hospitalization rates were notably higher in socioeconomically deprived areas.
- - The overall hospital fatality rate for HF was 10.2%, with a significant increase to 34.0% within a year; however, only 20.1% of patients were admitted to rehabilitation within six months.
- - The findings highlight the need for improved cardiovascular prevention strategies and adaptations in healthcare services across different regions in France, emphasizing the importance of better adherence to treatment guidelines.
Rationale and design of the PACIFIC-PRESERVED (PhenomApping, ClassIFication and Innovation for Cardiac dysfunction in patients with heart failure and PRESERVED left ventricular ejection fraction) study.
Jean-Sébastien Hulot Philip Janiak Philippe Boutinaud Pierre Boutouyrie Frédérique Chézalviel-Guilbert Richard Isnard
Arch Cardiovasc Dis
May 2024
Background: Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome that is poorly defined, reflecting an incomplete understanding of its pathophysiology.
Aim: To redefine the phenotypic spectrum of HFpEF.
Methods: The PACIFIC-PRESERVED study is a prospective multicentre cohort study designed to perform multidimensional deep phenotyping of patients diagnosed with HFpEF (left ventricular ejection fraction≥50%), patients with heart failure with reduced ejection fraction (left ventricular ejection fraction≤40%) and subjects without overt heart failure (3:2:1 ratio).