Publications by authors named "R Iskander"
Purpose: Participating in phase I cancer clinical trials often entails extra visits and procedures. We describe the planned time and procedures associated with phase I trial participation.
Methods: We searched ClinicalTrials.
Importance: Many cancer clinical investigators view clinical trials as offering better care for patients than routine clinical care. However, definitive evidence of clinical benefit from trial participation (hereafter referred to as the participation effect) has yet to emerge.
Objective: To conduct a systematic review and meta-analysis of the evidence examining whether patient participation in cancer trials was associated with greater survival benefit compared with routine care.
Article Synopsis
- Many cancer patients join clinical trials to access new treatments, but the actual benefits of these treatments, in terms of survival, have not been clearly established.
- A study analyzed 128 randomized trials for six solid tumors, finding that patients in experimental groups had statistically significant improvements in progression-free survival (1.25 months) and overall survival (1.18 months), despite smaller absolute gains.
- However, patients in experimental groups also experienced a higher risk of serious adverse events (7.4% increase), highlighting the need to weigh potential benefits against risks.
We conducted a systematic review and meta-analysis to evaluate the association between gestational diabetes mellitus and infections during pregnancy. We included cross-sectional, case-control, cohort studies and clinical trials, evaluating the frequency of infections in women with and without gestational diabetes mellitus. A search was conducted in Embase, PubMed, and Web of Science electronic databases and by manually searching references, until 23 March 2022, resulting in 16 studies being selected for review, with 111,649 women in the gestational diabetes mellitus group, and 1,429,659 in the controls.
View Article and Find Full Text PDFObjectives: To assess the effects of probiotic supplements on glycemic control and metabolic parameters in women with gestational diabetes mellitus (GDM) by performing a systematic review and meta-analysis of randomized controlled trials. The primary outcome was glycemic control, i.e.
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