Publications by authors named "R Invernizzi"
Article Synopsis
- - Idiopathic pulmonary fibrosis (IPF) is a severe lung disease with no cure besides lung transplantation, and its mechanisms are not fully understood.
- - Research indicates that a deficiency in the innate immune receptor TLR5 increases the risk of IPF in humans and raises vulnerability to lung damage and fibrosis in mice; activating TLR5 protects against these issues.
- - The protective effects of TLR5 are linked to its role in promoting healthy microbial balance in the lungs, with disrupted microbiomes seen in both IPF patients and TLR5-deficient mice.
Background: Adverse life occurrences (e.g., severe accidents, violence/abuse, organic disorders such as COVID-19) can elicit traumatic responses that heighten fear, anxiety, and depression.
View Article and Find Full Text PDFMotor deficit is a core symptom of Rett syndrome, a rare neurological disease caused in most cases by mutations of the () gene. Serotonin reuptake inhibitors improve motor coordination in heterozygous (Het) mice and serotonin depletion prevented this effect. Here, we assess alterations in indole levels in various brain regions and whether boosting brain serotonin synthesis with the serotonin precursors tryptophan, 5-hydroxytryptophan and α-lactalbumin rescued motor coordination deficit of Het mice.
View Article and Find Full Text PDFAdverse life events (e.g., severe accidents, violence/abuse, organic disorders) can elicit traumatic responses characterized by intrusive thoughts, hyperarousal, and avoidance-highlighting the need for sound assessment tools.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on colorectal cancer (CRC) with the BRAF V600E mutation, which is linked to poor patient outcomes and resistance to treatment, prompting a network meta-analysis to identify the best treatment options.
- Researchers systematically searched medical databases for studies involving patients with BRAF-mutated CRC who received first-line chemotherapy and analyzed survival data using hazard ratios (HRs).
- Results indicated that standard chemotherapy doublets, either alone or with bevacizumab, did not significantly improve overall survival (OS) or progression-free survival (PFS) compared to other treatment options, with the combination therapy showing the highest effectiveness score.