Publications by authors named "R Ihara"
Article Synopsis
- α-synuclein seed amplification assays (α-syn SAA) show promise but may have reduced sensitivity due to variations among patients with Lewy body disease (LBD).
- In a study of 34 Parkinson's disease (PD) patients and 7 with dementia with Lewy bodies (DLB), 85.2% of those with abnormal cardiac MIBG scans tested positive for α-syn SAA, while only 14.3% of those with normal scans did.
- MIBG cardiac scintigraphy was identified as a significant factor influencing α-syn SAA positivity, indicating that while α-syn SAA can be sensitive for LBD in specific cases, its effectiveness may be diminished in patients with normal M
Article Synopsis
- The study investigates public and clinical specialists' perceptions regarding preparedness for administering disease-modifying treatments (DMT) for Alzheimer’s disease, focusing on the newly approved drug lecanemab.
- Conducted through online and mail surveys, it gathered responses from over 2,000 participants, highlighting significant differences in views about treatment eligibility and efficacy between general public respondents and clinical specialists.
- While both groups were generally supportive of prioritizing patients for treatment, the public expressed more restrictive views on who qualifies for DMT and appeared more optimistic about its effectiveness compared to specialists.
Purpose: The aims of this study are to explore the apparent diffusion coefficient (ADC)-dependent thresholds for time to reperfusion in reversible lesions following mechanical thrombectomy for acute ischemic stroke, and to investigate the associated risks of hemorrhagic transformation.
Methods: We conducted a retrospective case-control study, enrolling patients with large-vessel occlusion who underwent mechanical thrombectomy in Otaru General Hospital from 2016 to 2021. Reversible lesions were identified using volumetric ADC data, and the mean time from image to reperfusion (TIR) in each ADC range was compared between groups with and without reversible lesions, as well as those with and without parenchymal hematoma.
Article Synopsis
- EUS-guided biliary drainage (EUS-BD) has shown good results in high-volume centers, but this study investigates its safety and effectiveness in newer centers that recently adopted the procedure.
- The research involved 22 centers from 2017 to 2022, assessing 255 patients and looking at the success and complications of EUS-BD performed by 84 endoscopists.
- The study found a high technical success rate of 91.4% but identified specific risks for failure and complications, including smaller puncture target diameters and moderate ascites, highlighting that the experience level of endoscopists did not significantly affect outcomes.
Article Synopsis
- Anti-amyloid drugs like lecanemab used for early Alzheimer's disease can cause adverse events (AEs), including specific brain imaging abnormalities and infusion reactions.
- A meta-analysis was conducted to assess the predictive value of these adverse events, revealing that ARIA-E has a high positive predictive value (PPV) of 0.915, while ARIA hemorrhage has a low PPV of 0.630.
- The findings indicate that the impact of AEs, especially ARIA-E, can influence the results of clinical trials and emphasize the need to reduce potential biases stemming from these events.