Publications by authors named "R Igarashi"
Article Synopsis
- Multiple myeloma (MM) is currently incurable, but natural killer (NK) cells show potential as a treatment option due to their role in targeting tumor cells.
- NK cells vary in their characteristics (like surface markers) and effectiveness, with certain subsets being linked to better patient outcomes, especially in relation to disease stages.
- Current MM treatments can influence NK cell behavior, suggesting that combining NK cell enhancements with existing therapies may improve overall treatment effectiveness.
Quantum sensing using the fluorescent nanodiamond (FND) nitrogen-vacancy center enables physical/chemical measurements of the microenvironment, although application of such measurements in living mammals poses significant challenges due to the unknown biodistribution and toxicity of FNDs, the limited penetration of visible light for quantum state manipulation/measurement, and interference from physiological motion. Here, we describe a microenvironmental thermometry technique using FNDs in rat mammary epithelium, an important model for mammary gland biology and breast cancer research. FNDs were injected directly into the mammary gland.
View Article and Find Full Text PDFBackground: The impact of parent-childbearing age on child development at 36 months of age is controversial.
Aims: We used data from a large cohort study with multiple imputation and mediation analyses of variables.
Methods And Procedures: A total of 72,606 parent-child pairs from the Japan Environment and Children's Study were included in the study.
NK cell therapeutics have gained significant attention as a potential cancer treatment. Towards therapeutic use, NK cells need to be activated and expanded to attain high potency and large quantities for an effective dosage. This is typically done by ex vivo stimulation with cytokines to enhance functionality or expansion for 10-14 days to increase both their activity and quantity.
View Article and Find Full Text PDFArticle Synopsis
- * To improve their ability to sense various physicochemical signals, grafting hydrophilic polymers like poly(ethylene glycol) (PEG) on NDs has been explored, particularly to minimize protein adsorption.
- * This study investigates the relationship between grafting conditions (like pH and molecular weight), crowding of PEG on NDs, and their effectiveness in preventing protein adsorption, demonstrating significant improvement in reduce lung accumulation after intravenous injection in mice.