Publications by authors named "R I Yakubovskaya"
Prostate cancer (PC) is the second most commonly occurring cancer in men. Conventional chemotherapy has wide variety of disadvantages such as high systemic toxicity and low selectivity. Targeted drug delivery is a promising approach to decrease side effects of therapy.
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- Upconversion nanoparticles (UCNPs) are advanced nanomaterials that enable high-contrast imaging for applications such as optical diagnosis, targeted drug delivery, and photodynamic therapy in the life sciences.
- Researchers developed UCNP-based nanocomplexes that bind specifically to HER2-positive cells, demonstrating effective tumor visualization for up to 24 hours in both cell cultures and animal models.
- Comprehensive safety evaluations showed that these UCNP nanocomplexes are noncytotoxic and biocompatible, indicating their potential for safe use in imaging and future clinical applications like image-guided surgery.
One of the main problems in oncology is the development of drugs that cause the death of cancer cells without damaging normal cells. Another key problem to be solved is to suppress the drug resistance of cancer cells. The third important issue is to provide effective penetration of drug molecules to cancer cells.
View Article and Find Full Text PDFBackground: Photodynamic therapy (PDT) is a promising technique for cancer treatment; however, low tissue permeability for irradiating light and insufficient photosensitizer (PS) accumulation in tumors limit its clinical potential. Nanoparticles are engineered to improve selective drug delivery to tumor sites, but its accumulation is highly variable between tumors and patients. Identifying PS accumulation peak in a personalized manner is crucial for therapeutic outcome.
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