A novel chaperone-effector-immunity system identified in uropathogenic UMN026.

Background: Urinary tract infections (UTIs) are very common worldwide. According to their symptomatology, these infections are classified as pyelonephritis, cystitis, or asymptomatic bacteriuria (AB). Approximately 75-95% of UTIs are caused by uropathogenic (UPEC), which is an extraintestinal bacterium that possesses virulence factors for bacterial adherence and invasion in the urinary tract.

Avulsion and Swallowing of a Primary Molar by a Toddler During Training Cup Use.

The purpose of this paper is to discuss the avulsion of a primary maxillary first molar in a 22-month-old child, which occurred while she had a training cup in her mouth. The parents noticed bleeding in the mouth and a missing tooth, and brought the child to a pediatric emergency department. A clinical assessment by the pediatric dental team confirmed the avulsion and since the tooth could not be located, a radiograph of the chest was obtained to rule out aspiration.

Cytotoxicity Analysis of Human Dental Pulp Stem Cells After Silver Diamine Fluoride Application.

The purpose of this study was to evaluate the cytotoxicity of silver diamine fluoride (SDF) to human dental pulp stem cells (hDPSC). hDPSC were exposed to dilutions of 38 percent SDF ( 10-3, 10-4, and 10-5) and incubated for 24 hours. Cell viability was assessed with colorimetric detection assay at 24 hours.

3,4-Dihydro-2(1)-Pyridones as Building Blocks of Synthetic Relevance.

3,4-Dihydro-2(1)-pyridones () and their derivatives are privileged structures, which has increased their relevance due to their biological activity in front of a broad range of targets, but especially for their importance as synthetic precursors of a variety of compounds with marked biological activity. Taking into account the large number of contributions published over the years regarding this kind of heterocycle, here, we presented a current view of 3,4-dihydro-2(1)-pyridones (). The review includes general aspects such as those related to nomenclature, synthesis, and biological activity, but also highlights the importance of as building blocks of other relevant structures.

A randomized, blinded, controlled trial to assess sand fly mortality of fluralaner administered orally in dogs.

Background: Leishmania infantum is the parasite responsible for the disease in humans known as zoonotic visceral leishmaniasis (ZVL). Dogs are considered the main domestic reservoir of ZVL and sand flies are the proven vectors. The use of systemic insecticides in dogs has been studied as an alternative strategy to control ZVL in endemic areas.