Publications by authors named "R I Novikova"

Orientation tuning and its dynamics of cat's primary visual cortex neurons located in pinwheel centers and orientation columns were studied during development of response in time. Functional domains in the Cortex were revealed by intrinsic signal optical imaging on functional and vascular maps of cortex. Both maps were used for precise placement of electrodes during recordings.

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In 22 acute experiments in anesthetized and immobilized adult cats the dynamics of 83 receptive fields (RF) of 47 striate neurons was studied by temporal slices method. Classical mapping revealed wave-like changes in the area and weight of neuronal RFs. Special mathematical analysis showed that such changes represented a sum of a slow non-oscillatory and comparatively fast components.

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Novel self-condensation of 3-(azol-5-yl)-1,1-dimethylenamines has been found to form new C-C bonds leading to 2,4-(1,2,3-triazole-1,2,3-thiadiazole-3-phenylisothiazole)-(1E,3Z)-5-yl-butadiene-1-amines. The discovered reaction represents a new example of C-H functionalization in unsaturated systems and can serve an efficient synthetic approach to rational design of new 2,4-(diazole-5-yl)-dieneamines.

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In 22 acute experiments on anesthetized and immobilized adult cats, the dynamics of 83 on- and/or off-receptive fields (RF) was studied in 47 striate neurons with the method of temporal slices by mapping with single-flash stimuli. The latency of the RF appearance was 88 +/- 5 ms, and its duration was 192 +/- 12 ms. Dynamical wavy changes in the RF sizes and weights repeating up to three times were revealed.

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Excitatory and inhibitory zones of receptive fields (RF) of detectors of cross-like figures and bars were studied in a primary visual cortex of cats under conditions of classical and combined mapping. Factor and correlation analysis demonstrated that detectors of bars and crosses differ in those interrelations, which are formed between the basic characteristics of neurons and their RF in each of group. The factor analysis of these connections showed that variables with the greatest weights, combined into the same factor, are different for different detectors.

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