Publications by authors named "R I Morimoto"
Article Synopsis
- Parkinson's disease (PD) is a progressive neurodegenerative disorder leading to both motor and non-motor symptoms that significantly impact patients' quality of life (QOL).
- This study examined the relationship between QOL and various factors in 102 PD patients, categorizing them by disease duration to identify key influences on their well-being.
- Findings showed that subjective non-motor symptoms and specific motor symptoms, particularly in patients with PD lasting over 5 years, were crucial in determining QOL, highlighting the need for a focus on patient-reported symptoms for better management.
A robust, practical, and sustainable isomerization-suppressed peptide bond formation via acyl sulfonamide, a twisted amide, is disclosed. Tosyl isocyanate and pentafluorobenzyl bromide were applied in combination to activate the peptide C-terminus, which then reacted with an amine to yield an elongated peptide with high stereochemical purity. Careful analysis of NMR spectra of the active intermediate revealed the presence of an intramolecular hydrogen bond, suggesting that the hydrogen bond suppressed Cα-epimerization during amidation.
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- - The study aimed to create a risk prediction model for in-hospital mortality in patients with cardiogenic shock (CS) receiving Impella support, as current models are insufficient.
- - Using the J-PVAD registry, researchers identified 12 key factors associated with mortality, including age, BMI, and certain lab results, which were included in the newly developed risk score.
- - The J-PVAD risk score demonstrates good accuracy and can be easily calculated in clinical settings, aiding healthcare professionals in making informed decisions about patient care.
Background: The number of older people in Japan is increasing more quickly than in other countries; with this aging of society, the number of elderly patients hospitalized for acute heart failure (HF) is also increasing. The treatment and prognosis of acute HF may be changing, but there are insufficient recent data, especially for octogenarian and older patients.
Methods And Results: This study investigated the characteristics and treatment of acute HF patients in Japan.
The Eczema Area and Severity Index is an investigator-assessed instrument reporting clinical signs of atopic dermatitis. The instrument is extensively validated in both adult and paediatric populations and recommended as a core outcome measure to assess clinical signs by the Harmonising Outcome Measures for Eczema initiative in clinical trials and was recently recommended as an option to measure signs in clinical practice. Here, we review the validation of the instrument using standard assessment criteria, explore controversies and challenges to its universal applicability and highlight future electronic adaptations.
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