Treatable Trait Guided Asthma Management: A Feasibility Study.

Background And Objectives: Treatable trait-based personalised medicine improves outcomes in severe asthma clinics. We assessed the feasibility of a randomised controlled trial (RCT) of protocolised treatable trait-guided asthma management in patients not under a severe asthma clinic.

Methods: Ten week single-group cohort study.

Mechanical thrombectomy for inferior vena cava tumor thrombus secondary to renal cell carcinoma.

This case describes the use of percutaneous mechanical thrombectomy to remove caval tumor thrombus in a 55-year-old male with renal cell carcinoma, using the Inari CloTriever system. The procedure was fast, safe, and effective, with complete tumor thrombus removal and no complications. This case demonstrates the expanding indications for large-bore thrombectomy devices offering minimally invasive options in place of high-risk open interventions.

Soluble CD52 mediates immune suppression by human seminal fluid.

Seminal fluid provides for the carriage and nutrition of sperm, but also modulates immunity to prevent allo-rejection of sperm by the female. Immune suppression by seminal fluid has been associated with extracellular vesicles, originally termed prostasomes, which contain CD52, a glycosylated glycophosphoinositol-anchored peptide released from testicular epithelial cells. Previously, we reported that human T cell-derived CD52, bound to the danger-associated molecular pattern protein, high mobility group box 1 (HMGB1), suppresses T cell function via the inhibitory sialic acid-binding immunoglobulin-like lectin-10 (Siglec-10) receptor.