[IMMUNOLOGICAL REACTIVITY AND CORRECTION OF IMMUNOLOGICAL DISORDERS BY BIOLOGICAL MEDICINES IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE EXACERBATIONS].

The results of systemic immunological reactivity research were presented in 97 patients with chronic obstructive pulmonary disease (COPD) exacerbations. The patients were randomized on two groups. 67 patients, which additionally to standard anti-inflammatory therapy were prescribed different combinations of homotoxicological medicines, entered in a clinical group.

[The characteristics of disorders of intracardiac hemodynamics and hemorheology in pulmonary heart failure].

Overall ninety patients with chronic obstructive bronchitis presenting with signs of varying degree cardiopulmonary insufficiency (CPI) were evaluated by radionuclide ventriculography with technetium pertechnetate as well as by rotational viscosimetry of blood. The degree of hemorheological derangements tended to get higher with CPI severity (light, moderately severe, severe) being accompanied by progressing impairement of systolic and diastolic functions of both ventricles of the heart. Mechanisms of compensation of endocardiac hemodynamics were realized as a result of increase in end-diastolic and end-systolic volumes of both ventricles together with changes in amplitude and time characteristics of processes of ventricular ejection and filling.

[The use of mildronate and trental in treating disorders of hemorheology and the intracardiac hemodynamics in patients with chronic obstructive bronchitis].

Overall ninety patients with chronic obstructive bronchitis presenting with signs of pulmonary-cardiac insufficiency (CPI) were studied by static radionuclide ventriculography with pertechnetate and rotation viscosimetry before and after a 14-day course of treatment. All the patients received basic treatment with cardiac glycosides on a differential basis depending upon CPI severity. Those patients having been prescribed mildronate additionally in a daily dose of 10 mg/kg body mass demonstrated improvement in left ventricular performance: the total and regional ejection fractions got increased, with the end-diastolic and end-systolic volumes having gotten reduced.

[Left ventricular function in patients with chronic obstructive bronchitis].

A study of 45 patients with chronic obstructive bronchitis by the method of radionuclide ventriculography with 99mTc showed that even the early stages of the disease were characterized by an inhibition of the contractile function of the left cardiac ventricle. With progression of respiratory insufficiency, maintaining of the left cardiac ventricle stroke volume is achieved by increase of the final-diastolic and final-systolic volumes. Appearance of signs of cardiac decompensation is accompanied by a breakdown of this compensatory mechanism accompanied by a reduction of the strike volume and diminished rate of contraction of the circular fibers of the left ventricle myocardium.