Street-scale black carbon modelling over the West Midlands, United Kingdom: Sensitivity test of traffic emission factor adjustments.

Black carbon is harmful for climate, environment, and human health. Road traffic is one of the major sources for black carbon in urban areas. This study develops a street scale air quality model configuration for the dispersion of black carbon concentrations across the West Midlands, UK, incorporating updated road traffic emission factors.

Permissive central tolerance plus defective peripheral checkpoints licence pathogenic memory B cells in CASPR2-antibody encephalitis.

Autoimmunity affects 10% of the population. Within this umbrella, autoantibody-mediated diseases targeting one autoantigen provide a unique opportunity to comprehensively understand the developmental pathway of disease-causing B cells and autoantibodies. While such autoreactivities are believed to be generated during germinal centre reactions, the roles of earlier immune checkpoints in autoantigen-specific B cell tolerance are poorly understood.

'You've gotta be a man and be strong': Pakistani fathers' experiences of perinatal loss.

Aims/background: Although women physically experience pregnancy, and grief might manifest differently, both mothers and fathers are affected similarly by perinatal loss. Research has predominately focused on Caucasian men, with the experiences of men from ethnic minority groups not researched. In the UK, the Pakistani community has one of the highest rates of perinatal loss, therefore this research aimed to explore the experiences of perinatal loss in Pakistani men.

Large-scale evaluation of outcomes after a genetic diagnosis in children with severe developmental disorders.

Purpose: We sought to evaluate outcomes for clinical management after a genetic diagnosis from the Deciphering Developmental Disorders study.

Methods: Individuals in the Deciphering Developmental Disorders study who had a pathogenic/likely pathogenic genotype in the DECIPHER database were selected for inclusion ( = 5010). Clinical notes from regional clinical genetics services notes were reviewed to assess predefined clinical outcomes relating to interventions, prenatal choices, and information provision.

Type 1 Diabetes Mellitus and Thromboembolism in Pregnancy.

Objective The impact of type 1 DM (T1DM) on thromboembolism in pregnancy is uncertain. We hypothesized that T1DM is associated with higher rates of thrombotic events during pregnancy and the postpartum period. Study Design This is a retrospective cohort study utilizing the National Inpatient Sample database from HCUP/AHRQ for 2017-2019.