[The long-term memory and learning capacity of rats with high brain seizure activity after an embryonic nerve tissue allograft].

Fragments of the embryonic hippocampus, septum, cerebellum and substantia nigra were grafted into the lesioned brain areas of 151 animals with phenotypical (bilateral destruction of the CA1 and CA4 hippocampal areas or the basolateral amygdalar regions in Wistar rats) and genotypic (in Krushinskiĭ-Molodkina strain) high seizure readiness. The parameters of long-term memory were improved after embryonic septal and cerebellar graftings, normalized after embryonic hippocampal graftings and were not improved after embryonic nigral graftings in both strains. Learning ability of the animals of both the strains with ceased audiogenic seizures was kept at the control level after the transplantation of embryonic tissue from the different brain areas.

[Threshold of sensitivity to epileptiform stimulus in intracerebral allotransplantation of embryonal nerve tissue of varying ergetics].

Effect of intracerebral allotransplantation of neocortex, hippocampus, septum, cerebellum, substantia nigra embryonic nerve tissue have been studied in white non-inbred, Wistar and Krushinski-Molodkina rats with phenotypically (portal destruction of hippocampus, gyrus serratus, corpus amygdaloideum and cerebral hypoxia) and genotypically conditioned by the low threshold of convulsive cerebral activity (TCCA). In focal cerebral affection transplants with monoergic neurones increase TCCA, while polyergic neurones of embryonic neocortex increase TCCA in diffuse cerebral affection. Phenotypically conditioned low TCCA increases in 4-6 days after transplantation and genotypically one--in 39-44 days because of the more complicated mechanisms of cerebral epileptization.

[The dynamics of phenotypically and genotypically determined high brain seizure activity in the intracerebral allografting of embryonic nerve tissue].

Experiments were made on rats of two lines during 120-140 days. A study was made of the effect of transplanting the embryonal hippocamp tissue and the septum (E 18) on the phenotypically (mechanical destruction in Wistar rats of the areas CA1 and CA4 of the fields of the hippocamp and dentate gyrus) and genotypically (Krushinskiĭ-Molodkina rats, all responding to graded acoustic stimulations (86 dB) by audiogenic convulsive fits) determined high convulsive activity of the brain. It has been shown that from days 4-6, in 19 out of 23 Wistar rats, the transplantation was followed by a steady increase of the threshold of convulsive activity.

[Synaptic structure of human cerebral cortex in chronic hypoxia and epileptic changes in the brain].

Comparative quantitative analysis of the synaptic pool of the neuropil in the molecular layer at the temporal epilepsy and cerebral chronic hypoxia (brain tumor, that is not accompanied with a convulsive syndrome) has been performed using biopsy material. As a control the brain of practically healthy persons, who died a sudden death, has been used. The contrasting method of the phosphoric tungsten acid alcohol solution and OsO4 has been applied.

[Structuro-functional organization and neurosurgical correction of mental seizures in epilepsy].

The structural-functional organization of psychic epileptic seizures was studied from the findings of complex clinicophysiological examination of 323 patients with epilepsy with the application of stereotaxically implanted long-term multiple intracerebral electrodes. Systemic organization of psychic seizures was determined with the presence of intermediate epileptic foci in the structures of the limbic system. It is shown that selective amygdalohippocampectomy is the most effective intervention in surgical correction of psychic seizures.