Publications by authors named "R I Dorn"
We evaluated a digital cognitive assessment platform, Philips IntelliSpace Cognition, in a case-control study of patients diagnosed with mild cognitive impairment (MCI) and cognitively normal (CN) older adults. Performance on individual neuropsychological tests, cognitive -scores, and Alzheimer's disease (AD)-specific composite scores was compared between the CN and MCI groups. These groups were matched for age, sex, and education.
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- * Traditional tools for studying RNA often suffer from high background signals due to their constant activation or reliance on UV light; this study introduces a new method using bioorthogonal cyclopropenones (CpOs) for more selective RNA cross-linking.
- * The research demonstrates the effectiveness of CpO by showing it can create covalent cross-links with a specific RNA aptamer, offering a promising approach for investigating RNA in its natural state and expanding research tools in molecular biology.
RNA sequences encode secondary and tertiary structures that impact protein production and other cellular processes. Misfolded RNAs can also potentiate disease, but the complete picture is lacking. To establish more comprehensive and accurate RNA structure-function relationships, new methods are needed to interrogate RNA and trap native conformations in cellular environments.
View Article and Find Full Text PDFResearch of the nontraditional polysaccharide gellan gum (GG) is a growing space for the development of novel drug delivery systems due to its tunable physic-mechanical properties, biocompatibility, and stability in a wide range of environments. Unfortunately, high temperature crosslinking is often required, representing a limiting factor for the incorporation of thermosensitive therapeutic agents. Here, we demonstrated that GG can be crosslinked at a low temperature (38 °C) using a simple fabrication process that utilizes trilysine as an alternative to traditional mono- or divalent ion crosslinkers.
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- The study investigates the role of the CHRFAM7A gene in human neuropsychiatric disorders like Alzheimer's, schizophrenia, and anxiety, focusing on its influence on brain structure and function.
- Researchers conducted a genotype analysis on 46 healthy subjects to compare those who carry the gene's direct allele with those who don’t, assessing neuropsychological performance and conducting MRI scans for structural brain analysis.
- Findings from cognitive tests and MRI scans were analyzed through age-adjusted statistical methods to identify how CHRFAM7A may affect brain and cognitive functions.