Publications by authors named "R I Desai"
Background: Pulmonary hypertension (pHTN) has been associated with increased morbidity and mortality after mitral Transcatheter Edge-to-Edge Repair (TEER), but the association remains uncertain. This study aims to evaluate the impact of pHTN on cardiovascular outcomes following TEER.
Methods: We searched PubMed, Scopus, and Medline to identify studies reporting outcomes after TEER in individuals with pHTN.
Purpose: Increasing physical activity (PA) is safe and associated with improved health outcomes in patients with metastatic breast cancer (MBC). Mobile health (mHealth) PA interventions that allow for remote monitoring and tailoring to abilities may be particularly useful for MBC patients. However, limited data exist on the acceptability of these interventions for MBC patients.
View Article and Find Full Text PDFBackground: The evidence informing the harms of gabapentin use are at risk of bias from comparing users with nonusers.
Objective: To describe the risk for fall-related outcomes in older adults starting treatment with gabapentin versus duloxetine.
Design: New user, active comparator study using a target trial emulation framework.
Article Synopsis
- One in ten women of reproductive age have PCOS, characterized by subfertility, high LH levels, and potential dysfunction in the kisspeptin neurons that regulate GnRH.
- Researchers studied the GnRH pulse generator in two mouse models of PCOS: the peripubertal androgen (PPA) model showed fewer synchronized neuron events, while the prenatal androgen (PNA) model revealed variable GnRH activity but cyclical patterns indicating complexity.
- Findings indicate that in the PNA model, ARN neurons had increased activity during specific stages and less sensitivity to progesterone, highlighting the need to understand GnRH regulation in PCOS-related conditions.
Dysfunction of the endo-lysosomal intracellular Cholesterol transporter 2 protein (NPC2) leads to the onset of Niemann-Pick Disease Type C (NPC), a lysosomal storage disorder. Metabolic and homeostatic mechanisms are disrupted in lysosomal storage disorders (LSDs) hence we characterized a cellular model of NPC2 knock out, to assess alterations in organellar function and inter-organellar crosstalk between mitochondria and lysosomes. We performed characterization of lipid alterations and confirmed altered lysosomal morphology, but no overt changes in oxidative stress markers.
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