[THE BIOMARKERS OF MYOCARDIAL DAMAGE AND THEIR ROLE IN THE PROGRESSION OF HEART FAILURE (REVIEW)].

Despite the success achieved in the study and treatment of chronic heart failure, this syndrome still remains one of the most difficult and predictable unreliable pathologies. Moreover, in recent years there has been a tendency of growth of such patients. Based on the above, the attention of scientists focuses on new concepts that involve the study of new biomarkers of cardiac damage and the definition of their role in the progression of heart failure.

[Metabolic issues of ischemia induced myocardial dysfunction].

Myocardial ischemia represents most common cause of necrosis of cardiomyocytes, cardio sclerosis and heart failure. Main clinical manifestation of myocardial ischemia is systolic and/or diastolic dysfunction. It has been shown, that local disturbance of myocardial contractility is not always determined by cell necrosis and cardio sclerosis, as improvement of coronary perfusion may lead to restoration of contractile function of myocardium.

[Ventricular arrhythmias and sudden cardiac death].

Sudden cardiac death (SCD) - this natural death caused by cardiac reasons and which is characterized by sudden loss of consciousness within first hour after revealing of sharp clinical symptoms. A primary factor of SCD is not traumatic. It occurs suddenly and unexpectedly.

[Prevention of thrombolitic compications with atrial fibrillation].

This study presents the modern principles of prevention and treatment of thrombolitic complications in patients with atrial fibrillation. The adequate tactics and algorithm of antithrombotic therapy in the case of variety versions of this disease is considered in this study. It described the efficiency and safety of oral anticoagulants (antagonist Vit K) varfarin with the purpose to inform the practical doctors with principals of prevention and treatment of hemorrhagic complications.

[Role of immune inflammatory activity in chronic heart failure progress].

Significant role of immune inflammatory reactions along with activation of the RAAS (rennin-angiotensin-aldosterone system) and the sympatho-adrenal system in CHF (chronic heart failure) pathogenesis is considered in the present survey article. Together with haemodynamic disorders activation of inflammatory reactions, which involve anti-inflammatory cytokines, is shown to be one of the main factors affecting CHF course and prognosis. Alteration of cytokine level is associated with injury level, gravity of the disease course and its clinical outcome.