Publications by authors named "R Hurford"
Article Synopsis
- Hypophosphatemia is frequently observed in critically ill patients admitted to Intensive Care Units (ICUs), with a study examining its prevalence and outcomes in Queensland, Australia between 2015 and 2021.
- Out of 89,776 patients, 68,699 were included, and 34.2% experienced hypophosphatemia, typically identified on the second day of ICU stay and resolved within three days.
- The severity of hypophosphatemia correlated with increased 90-day mortality rates, with moderate and severe cases showing significantly higher fatality risks compared to those without hypophosphatemia.
Introduction: In critically ill patients undergoing continuous renal replacement therapy (CRRT), a positive fluid balance (FB) is associated with adverse outcomes. However, current FB management practices in CRRT patients are poorly understood. We aimed to study FB and its components in British and Australian CRRT patients to inform future trials.
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- Positive fluid balance (FB) is linked to increased mortality in ICU patients with acute kidney injury (AKI), developing mainly due to high fluid input, low urine output, and limited diuretic use.
- AKI typically manifests around two days after ICU admission, where even though fluid resuscitation was minimal, FB peaked on the third day due to ongoing crystalloid and nutritional fluid usage.
- The study suggests that continuous fluid administration without adequate urine output and low diuretic intervention may worsen patient outcomes in those with AKI.
Purpose: The Acute Disease Quality Initiative (ADQI) Workgroup recently released a consensus definition of sepsis-associated acute kidney injury (SA-AKI), combining Sepsis-3 and Kidney Disease Improving Global Outcomes (KDIGO) AKI criteria. This study aims to describe the epidemiology of SA-AKI.
Methods: This is a retrospective cohort study carried out in 12 intensive care units (ICUs) from 2015 to 2021.
Stroke is a common neurological emergency and although most cases are associated with traditional vascular risk factors leading to cerebral ischaemia by well-recognised pathophysiological mechanisms, around 4% of ischaemic strokes are due to rare conditions. These are important to recognise due to their different management, which is often specific and effective, and due to their different prognosis from otherwise cryptogenic ischaemic strokes. We outline a practical approach to identifying uncommon causes of ischaemic stroke by highlighting diagnostic 'red flags' and propose a structured approach to investigating them.
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