Publications by authors named "R Hugo"

Introduction: Thyroid cancer is the most common cancer in women in Ecuador.

Objective: The aim of this study was to determine the demographics and clinical and treatment variables of patients with papillary or follicular thyroid cancer, referred to as differentiated thyroid cancer (DTC), treated at a third-level hospital in Quito, Ecuador.

Methods: We reviewed retrospectively the medical records of patients with DTC, who underwent surgical treatment, from 1990 to 2019.

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The advancement of safe nanomaterials for use as optical coherence tomography (OCT) imaging and stem cell-labeling agents to longitudinally visually track therapeutic derived retinal stem cells to study their migration, survival rate, and efficacy is challenged by instability, intracellular aggregation, low uptake, and cytotoxicity. Here, we describe a series of hybrid lipid-coated gold nanorods (AuNRs) that could solve these issues. These nanomaterials were made via a layer-by-layer assembly approach, and their stability in biological media, mechanism, efficiency of uptake, and toxicity were compared with a commercially available set of AuNRs with a 5 nm mesoporous silica (mSiO)-polymer coating.

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Article Synopsis
  • High levels of acute phase proteins can indicate worse outcomes in various cancers, but their impact on acute myeloid leukemia (AML) wasn't previously understood.
  • Researchers studied 282 newly diagnosed AML patients undergoing chemotherapy and created a new score, the CFA ratio, based on C-reactive protein, fibrinogen, and albumin levels.
  • Patients with a CFA ratio below 3.06 had significantly better progression-free, disease-free, and overall survival rates, suggesting that elevated CFA ratios and modified Glasgow prognostic scores are linked to poorer outcomes in AML, warranting further evaluation for risk assessment.
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Background: Outdoor, early-biting, zoophagic behaviours by Anopheles farauti (s.s.) can compromise the effectiveness of bed nets for malaria control.

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Proteomic investigations in Anopheles gained momentum following the sequencing of the Anopheles gambiae genome, allowing peptide data from mass spectrometry to be searched against large datasets of predicted protein sequences. Exhaustive discovery proteomics investigations have improved the annotation of genomic datasets and catalogued proteins from mosquito tissues, including the salivary glands, midgut, and sensory appendages. These efforts have revealed protein constituents that define the unique biological functions of these organs.

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