Comparison of antidiuretic and natriuretic effects of [8-lysine]vasopressin and [8-D-arginine]deaminovasopressin in conscious rats.

The relation between the duration of antidiuresis and sodium excretion and the route of administration of [8-lysine-vasopressin or [8-D-arginine]-deaminovasopressin to conscious rats was investigated. Both compounds were administered either intravenously through a chronically inserted catheter in the right jugular vein, or subcutaneously. The rats were then placed into individual metabolic cages and urine was collected quantitatively.