Publications by authors named "R Homburg"
Article Synopsis
- The 2024 Australian evidence-based guideline offers recommendations for diagnosing and treating unexplained infertility in couples, tailored specifically for the Australian healthcare context and approved by national health authorities.
- The guideline contains 40 evidence-based recommendations, addressing areas such as defining infertility, diagnosing various factors contributing to infertility, and treatment options, with a focus on improving patient care.
- Key updates include a refined definition of unexplained infertility and a more comprehensive assessment process, integrating considerations of evidence quality, safety, and practicality for implementing these guidelines in Australia.
Background: There is no consensus on tests required to either diagnose unexplained infertility or use for research inclusion criteria. This leads to heterogeneity and bias affecting meta-analysis and best practice advice.
Objectives: This systematic review analyses the variability of inclusion criteria applied to couples with unexplained infertility.
Abstract: Embryo implantation is vital for successful conception but remains to be fully understood. Trophoblast invasion is key for implantation, with anchorage and depth of placentation determined by its extent. There is a dearth of synchronous information regarding IVF, implantation site, and trophoblastic thickness (TT).
View Article and Find Full Text PDFMost aspects of in-vitro fertilisation (IVF) have changed dramatically since introduction, but embryo transfer (ET) technique remains largely unaltered. We aimed to determine whether four-dimensional ultrasound guided embryo transfers (4D UGET) could improve pregnancy rates when compared with clinical touch technique (CTT). This was a single centre open labelled randomised controlled trial in a tertiary fertility centre in the UK.
View Article and Find Full Text PDFStudy Question: What is the recommended management for couples presenting with unexplained infertility (UI), based on the best available evidence in the literature?
Summary Answer: The evidence-based guideline on UI makes 52 recommendations on the definition, diagnosis, and treatment of UI.
What Is Known Already: UI is diagnosed in the absence of any abnormalities of the female and male reproductive systems after 'standard' investigations. However, a consensual standardization of the diagnostic work-up is still lacking.