Influence of heavy metals upon the retention and mobilization of polonium-210 in rats.

Purpose: To provide information about the tissue retention and mobilization of the alpha-emitting radionuclide, polonium-210 (210Po), in rats under combined exposure to heavy metal ions and the chelating agent, 2, 3-dimercaptopropane-1-sulfonate (DMPS).

Materials And Methods: Rats were pre-exposed intraperitoneally to either CdCl2 or Pb(CH3COO)2. 9 or 15 h later they received 210Po nitrate intravenously.

Reduction of subacute lethal radiotoxicity of polonium-210 in rats by chelating agents.

The protective effect of N,N'-di(2-hydroxyethyl)ethylene-diamine-N,N'-biscarbodithioate (HOEtTTC) against the subacute lethal radiotoxicity of polonium-210 was investigated in a survival study and by histopathological and haematological examinations of some organs and tissues in Sprague-Dawley rats. This effect was compared with that of N,N'-diethylamine-N-carbodithioate (diethy dithiocarbamate, DDTC). In the survival study, rats injected in intravenously solely with a lethal amount of 210Po (1.

Effects of magnetic field exposure on the development of lung fibrosis elicited by industrial pollutants.

Lung injury elicited by a single intratracheal instillation of fibrogenic (quartz) and nuisance (anatase) dusts and/or weekly repeated instillation of CdCl2 solution combined with sinusoidal (50 Hz, 10 mT) magnetic field (MF) exposure was studied in male rats. Combined effects in bronchoalveolar lavage (BAL), rat lungs and regional lymph nodes after 4 months of MF exposure (1 h/5 days per week) were evaluated biochemically and by cytological and histopathological examination. Damage of cell membranes in the cell part of BAL due to MF exposure was not observed in the examined animal groups.

[Serum lysozyme and copper levels in rats after the administration of dust].

Changes in the content of lysozyme and copper were studied in the blood serum of rats in four time intervals (1, 2, 12, and 24 weeks) after administration of 50 mg TiO2, Sio2 or coal dust and the copper content was also studied 12 weeks after administration of 3 industrial dusts. The obtained results were supplemented by histopathological examinations and in the 12-week interval by the determination of the lung wet weight. The lysozyme content was statistically significantly increased compared to controls practically over the whole time course with differences in the level of the response to SiO2 in comparison with the response to TiO2 and coal.