Basic Science and Pathogenesis.

Background: Results of recent analyses indicate that axon demyelination may play an important role in AD pathology. The MBP gene encodes a myelin basic protein involved in axon myelination in the nervous system including the central nervous system. Polymorphisms in this gene, as well as variations in expression, have been associated with multiple sclerosis (MS).

Territory Sizes and Patterns of Habitat Use by Forest Birds Over Five Decades: Ideal Free or Ideal Despotic?

Relations among territoriality, abundance and habitat suitability are fundamental to the ecology of many animal populations. Theory suggests two classes of possible responses to increasing abundance in territorial species: (1) the ideal free distribution (IFD), which predicts smaller territory sizes and decreased fitness as individuals adaptively pack into suitable habitats, and (2) the ideal despotic distribution (IDD), which predicts stable territory sizes and fitness in preferred habitats for dominant individuals and increased use of marginal habitats, reduced fitness and changes in territory sizes for subordinate individuals. We analysed the territory sizes and locations of seven migratory songbird species occupying a 10-ha plot in the Hubbard Brook Experimental Forest, New Hampshire, USA over a 52-year period.

Assessing Regional Strategies to Cope with Drought, Climate, and Environmental Flow Policy Impacts for a Sustainable Water Supply: A Case Study of the Bay Area.

California's Bay-Delta watershed encompasses 40% of the state's runoff and serves water supply and irrigation needs throughout the state. A recently amended policy attempts to rebalance water supply and ecological outcomes by requiring 40% of the flow to remain in-stream in the Tuolumne River and other tributaries between February 1 and June 30 each year. This policy impacts water supply diversions serving millions of customers in the San Francisco Bay Area.