Publications by authors named "R Hirayama"

Delayed cardiac tamponade following blunt chest trauma is a rare incident, and we provide a report including a literature review for further discussion. The patient is a 56-year-old male. He fell off a motorcycle and sustained contusions to the left side of his chest.

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Radioresistant tumours remain complex to manage with current radiotherapy (RT) techniques. Heavy ion beams were proposed for their treatment given their advantageous radiobiological properties. However, previous studies with patients resulted in serious adverse effects in the surrounding healthy tissues.

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Background: N-butyl cyanoacrylate (n-BCA) is often used for preoperative transarterial embolization (TAE) of meningiomas. However, factors affecting the embolization effect with n-BCA remain unclear. This study aimed to clarify the factors associated with the embolization rate after TAE using n-BCA in meningioma, from the aspect of feeder architecture.

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O6-methylguanine DNA methyltransferase promoter methylation is an important clinical biomarker of newly diagnosed glioblastoma. Previous radiological studies using dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) perfusion have aimed to predict methylation status non-invasively in gliomas with radiological characteristics. The possibility of predicting methylation status using DSC-MRI perfusion with a radiological approach remains controversial.

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Article Synopsis
  • Glioblastoma multiforme (GBM) is a highly aggressive brain tumor that urgently needs new therapies; CAR T cell therapy has shown promise but is costly and time-intensive.
  • Researchers are exploring CAR-transduced natural killer (NK) cells as an "off-the-shelf" immunotherapy alternative, which can avoid complications like graft-versus-host disease.
  • Both CAR-T and CAR-NK cells targeting the B7-H3 protein demonstrated significant effectiveness in killing GBM cells in lab tests and in animal models, suggesting they could be viable treatment options for this aggressive cancer.
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