Publications by authors named "R Hesterberg"
Systemic levels of methylmalonic acid (MMA), a byproduct of propionate metabolism, increase with age and MMA promotes tumor progression via its direct effects in tumor cells. However, the role of MMA in modulating the tumor ecosystem remains to be investigated. The proliferation and function of CD8 T cells, key anti-tumor immune cells, declines with age and in conditions of vitamin B12 deficiency, which are the two most well-established conditions that lead to increased systemic levels of MMA.
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- Integrative analysis of expression data is tough due to varying factors like sample processing and RNA quality, making it hard to remove unwanted batch effects effectively.
- The BatchFLEX Shiny app helps visualize and correct these batch effects using different methods, illustrating their impact on gene expression in immune cells.
- The tool is accessible on GitHub and Shiny.io, with additional supplementary data available online for further reference.
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- Glutaminolysis is essential for T cell activation and metabolic changes, with glutamine serving as a key carbon source for producing polyamines—putrescine, spermidine, and spermine.
- These polyamines are crucial for T cell proliferation and the production of hypusine, which is important for protein synthesis in T cells.
- Inhibiting the glutamine/polyamine/hypusine pathway enhances memory T cell development and boosts the immune response in both human CD8+ T cells and CAR-T cells, suggesting potential therapeutic strategies.
Chronic T-cell receptor (TCR) signaling in the tumor microenvironment is known to promote T-cell dysfunction. However, we reasoned that poorly immunogenic tumors may also compromise T cells by impairing their metabolism. To address this, we assessed temporal changes in T-cell metabolism, fate, and function in models of B-cell lymphoma driven by Myc, a promoter of energetics and repressor of immunogenicity.
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- Ultraviolet radiation exposure is a known risk factor for cutaneous squamous cell carcinoma (cuSCC) and is linked to increased levels of immunosuppressive regulatory T cells (Tregs).
- This study aimed to evaluate whether higher levels of specific Tregs, particularly CCR4, are associated with the development of cuSCC in individuals exposed to high levels of UVR.
- Results indicated that individuals with elevated circulating CCR4 Tregs at baseline have a significantly increased risk of developing cuSCC, especially those exposed to high UVR, highlighting the potential for these Tregs as indicators for skin cancer risk and future research opportunities.