Publications by authors named "R Herrera Franco"
Non-alcoholic fatty liver disease (NAFLD) is a common hepatic manifestation of metabolic syndrome affecting 20-30 % of the adult population worldwide. This disease, which includes simple steatosis and non-alcoholic steatohepatitis, poses a significant risk for cardiovascular and metabolic diseases. Lifestyle modifications are crucial in the treatment of NAFLD; however, patient adherence remains challenging.
View Article and Find Full Text PDFBackground: Oligo-metastatic disease (OMD) in colon cancer patients exhibits distinct clinical behavior compared to poly-metastatic disease (PMD), with a more responsive and indolent course. This study aims to identify clinical and biological factors uniquely associated with oligo-metastatic behavior.
Methods: Metastatic colon cancer patients from an academic center underwent genetic characterization.
Application of Human Papillomavirus-DNA Test on Salivary Gland Fine Needle Aspiration Cytology Samples Confirms the Absence of the Virus in Primary Neoplasms and Demonstrates for the First Time Its Presence in Salivary Intraglandular Cysts.
Diagn Cytopathol
December 2024
Article Synopsis
- The study explored the connection between Human Papillomavirus (HPV) and salivary gland tumors, which remains unclear in existing literature.
- The research involved 66 salivary gland lesions, using fine needle aspiration cytology to detect HPV-DNA, resulting in HPV found in two cysts and three metastatic carcinomas, but none in primary tumors.
- Ultimately, the study concluded that HPV did not play a role in primary salivary gland tumors, but its presence in intraglandular cysts suggests a new area for further investigation.*
Article Synopsis
- - The study aimed to examine the connection between sleep bruxism (unconscious teeth grinding) and factors like sleep quality, stress, and dental health in children aged 6-12.
- - A total of 384 children participated, with parents providing reports on bruxism, sleep quality, and stress levels; certain children were excluded based on health conditions or lack of consent.
- - Results indicated that sleep bruxism in children is significantly related to poor sleep quality and higher stress levels, suggesting it may impact their overall dental health.
Article Synopsis
- GPR88 is an orphan G protein-coupled receptor primarily found in the striatum, and its function is not well understood despite changes in its expression seen in Parkinson's disease models.
- GPR88 was found to interact with the kappa-opioid receptor (KOR), and this interaction inhibits KOR-mediated signaling, as evidenced by experiments showing that GPR88 can modulate effects of KOR agonists in both cultured cells and primary striatal neurons.
- The GPR88-KOR complexes were more common in specific neurons related to dopamine pathways, suggesting that understanding their relationship could have implications for conditions like neuropathic pain, Parkinson's disease, and neuropsychiatric disorders.