Publications by authors named "R Hernandez-Pando"
Tuberculosis (TB) is a global health problem with diverse clinical manifestations. Different cells of the immune response participate in containing the infection, mainly through the development of granulomas. Mast cells (MCs) are hematopoietic cells that participate in the immune response to different pathogens, and in vitro evidence indicates that they can be activated by Mycobacterium tuberculosis (Mtb).
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- Ursolic acid (UA) and oleanolic acid (OA) are natural compounds with anti-mycobacterial properties but have poor solubility, limiting their use in treatment.
- Researchers developed solid lipid microparticles (SLMs) to effectively deliver UA and OA, demonstrating their ability to inhibit both drug-sensitive and multidrug-resistant tuberculosis (Mtb) in lab tests.
- In mouse models, the delivery of SLMs via inhalation significantly reduced bacterial loads and improved survival rates without causing toxicity, showcasing their potential as a safe and effective treatment option for tuberculosis.
Article Synopsis
- COVID-19, caused by the SARS-CoV-2 virus, triggers an uncontrolled immune response that leads to harmful inflammation and lung damage.
- Mast cells (MCs), known for their role in inflammation, are linked to severe COVID-19 cases, particularly through their mediator carboxypeptidase A3 (CPA3).
- The study found that in severe COVID-19 cases, increased CPA3-expressing MCs correlate with the development of pulmonary fibrosis (PF), indicating that excessive inflammation contributes to ongoing tissue damage and impaired healing.
To determine if fluoride's established negative impact on adult kidney health begins during gestation, an intergenerational model of Wistar rats was exposed to two doses of fluoride (2.5 or 5.0 mg/kg/day via gavage) 20 days before mating and during gestation (20 days).
View Article and Find Full Text PDFTuberculosis (TB) is an infectious, chronic, and progressive disease occurring globally. Human TB is caused mainly by Mycobacterium tuberculosis (M. tuberculosis), while the main causative agent of bovine TB is Mycobacterium bovis (M.
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