Publications by authors named "R Henschler"
Total Thrombus-Formation System in Patients with Peripheral Artery Disease.
Clin Appl Thromb Hemost
November 2024
Article Synopsis
- The Total Thrombus-formation Analysis System (T-TAS) is an automated tool designed to evaluate thrombus (blood clot) formation under simulated blood flow conditions, particularly in patients receiving antiplatelet therapy.
- This study examined T-TAS's effectiveness in detecting responses to dual antiplatelet therapy (DAPT) among 60 patients with peripheral artery disease (PAD) after a surgical procedure.
- Findings indicated that the platelet-chip (PL-chip) of T-TAS was able to identify low responders to DAPT more effectively than traditional aggregation tests, suggesting it could be a useful tool for monitoring treatment responses in PAD patients.
Background: The management of blood supply depends, among other factors, on the effective remobilization of first-time donors (FTDs). This study investigates the efficacy of telephone calls to increase second donation rates.
Study Design And Methods: A randomized controlled trial was conducted on 418 first-time blood donors.
Article Synopsis
- The study investigates how well the diluted Russel's Viper Venom Time (dRVVT) tests can detect leftover activity from direct oral anticoagulants (DOAC) in patients, aiming to find an efficient screening method for this purpose.
- A total of 80 patients received one of four DOAC medications, and their blood was tested at various times to measure dRVVT alongside DOAC plasma levels.
- Results show that while dRVVT is very effective at indicating significant levels of DOAC, especially with the LA2 assay, it can help in emergency settings to quickly assess anticoagulant effects and make treatment decisions.
Introduction: Reporting of transfusion reactions is good practice and required by many guidelines. Errors in the transfusion chain can also lead to severe patient reactions and depend on active error reporting. We aimed to characterize transfusion incidents and asked whether workup of transfusion reactions may also contribute to revealing logistical errors.
View Article and Find Full Text PDFA direct regulation of adaptive immunity by the coagulation protease activated protein C (aPC) has recently been established. Preincubation of T cells with aPC for 1 hour before transplantation increases FOXP3+ regulatory T cells (Tregs) and reduces acute graft-versus-host disease (aGVHD) in mice, but the underlying mechanism remains unknown. Because cellular metabolism modulates epigenetic gene regulation and plasticity in T cells, we hypothesized that aPC promotes FOXP3+ expression by altering T-cell metabolism.
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