Publications by authors named "R Hegarty"
Background: Pediatric acute liver failure (PALF) is a rare and life-threatening condition. In up to 50% of PALF cases, the underlying etiology remains unknown during routine clinical testing. This lack of knowledge complicates clinical management and liver transplantation decisions.
View Article and Find Full Text PDFArticle Synopsis
- Acute liver failure (ALF) is a rare, serious condition that usually requires emergency liver transplantation for effective treatment.
- Diagnosing ALF can be difficult, and historically, many cases in children had unknown causes; however, advances in genomic medicine are improving diagnosis rates, particularly identifying inherited genetic disorders as causes.
- The review emphasizes the importance of rapid genomic sequencing to differentiate between various inherited metabolic disorders that cause ALF, which can have different treatment strategies and prognoses.
Globally, there is a focus on reducing the absolute methane (CH) and nitrous oxide emissions, and the emissions intensity (EI, kg COe/kg animal product) of livestock production. Increasing the productivity of mixed pasture systems has the potential to increase food (e.g.
View Article and Find Full Text PDF