Publications by authors named "R Heer"
Aims: There is a growing body of evidence demonstrating the benefit of flash glucose monitoring in type 2 diabetes mellitus (T2DM). This individual patient data meta-analysis aimed to investigate the impact of commencing flash glucose monitoring on HbA1c in people living with T2DM treated with insulin in a real-world setting.
Methods: A meta-analysis of eight observational studies which assessed change in HbA1c at 3-6 months following initiating flash glucose monitoring for which Abbott Diabetes Care could provide individual patient data was performed.
Article Synopsis
- Cystoscopy has improved bladder cancer diagnosis, but there's variability among experts in assessing tumor stage and grade, prompting the integration of AI to enhance image analysis.
- A systematic review and meta-analysis will be conducted using articles from specified databases published between May 2015 and April 2024, focusing on studies utilizing AI for cystoscopic image analysis of bladder cancer.
- No ethical clearance is needed for this review, and the findings will be shared through peer-reviewed publications and conferences.
Article Synopsis
- Globally, while people are living longer, many experience a decline in health due to age-related diseases, highlighting the need for better classification systems to address these issues.
- A consensus meeting with 150 experts established criteria for identifying ageing-related pathologies, requiring a 70% agreement for approval among participants.
- The agreed criteria focus on conditions that progress with age, contribute to functional decline, and are backed by human studies, setting a foundation for future classification and staging efforts.
Article Synopsis
- Bone metastasis frequently occurs in advanced prostate cancer, and while bisphosphonates help manage symptoms, there are no curative options; the enzyme ST6GAL1, upregulated in such cancers, drives tumor growth and spread through altered glycosylation processes.
- The study monitored ST6GAL1 levels in tumor and serum samples from patients, revealing that its upregulation is linked to prostate cancers that have metastasized to bone, promoting bone metastasis through various mechanisms.
- Findings suggest that inhibiting sialylation can prevent tumor spread, indicating a potential new therapeutic strategy centered on sialic acid blockade for treating advanced prostate cancer.