Publications by authors named "R Hatano"
In hypoxic pulmonary hypertension (PH), pulmonary vascular remodeling is characterized by the emergence of activated adventitial fibroblasts, leading to medial smooth muscle hyperplasia. Previous studies have suggested that CD26/dipeptidyl peptidase-4 (DPP4) plays a crucial role in the pathobiological processes in lung diseases. However, its role in pulmonary fibroblasts in hypoxic PH remains unknown.
View Article and Find Full Text PDFAcute T cell mediated rejection of allografts remains a significant risk factor for early graft loss. Our prior work defined a population of graft-specific CD8 T cells positive for the activated receptor CD43 (expressing the 1B11 epitope) that form during acute rejection, leading us to further understand the in vivo fate and clinical relevance of this population. We found that during acute rejection, the CD43 ICOS phenotype was sensitive for proliferative graft-specific CD8 T cells.
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- A 59-year-old female with multiple myeloma developed symptoms of edema and dyspnea after starting treatment with carfilzomib, a cancer drug, which raised concerns about potential drug-related cardiac complications.
- Diagnostic tests revealed signs of pre-capillary pulmonary hypertension (PH) and confirmed it through right heart catheterization, leading to the conclusion that carfilzomib was causing the condition.
- After stopping the drug and starting pulmonary vasodilator therapy, the patient experienced symptom improvement and heart changes, suggesting the need for careful monitoring for PH in patients receiving carfilzomib.
Article Synopsis
- CD26 is a T cell costimulatory molecule and its levels are usually increased in autoimmune diseases, but decreased in patients with systemic lupus erythematosus (SLE), indicating a unique aspect of SLE pathology.
- In this study, researchers analyzed CD26+ and CD26(-) T cell populations from SLE patients, finding an abnormal rise in CD26(-) T cells that display characteristics similar to natural killer T cells.
- The study suggests that evaluating CD26(-)CD28(-) T cell populations may help in understanding and classifying the complex nature of SLE, particularly since their levels can vary significantly even among inactive patients.
Diabetes mellitus is induced by quantitative and qualitative decline in pancreatic β cells. Although its radical therapy has not yet been established, β cell regeneration is a promising option. We investigate here two mouse models of β cell regeneration induced after ∼80% reduction in β cell number: Cre/loxP-mediated β cell ablation and partial pancreatectomy.
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