Resource Realities: Exploring the Foundations of Successful Implementation in School-Based Drug Prevention.

Background: Comprehensive health education in schools can effectively prevent drug use and related outcomes, but successful implementation remains challenging. Contextual determinants, including intervention-setting compatibility, focus on the intervention, available resources, and leadership support, influence implementation success. This study investigates the impact of multilevel contextual determinants on Michigan Model for Health: (MMH) curriculum fidelity.

The Centering of Youth Voice in the Development of a Virtual, Instructor-Led Physical Activity Program.

Background: Providing youth the opportunity to express their attitudes toward and recommendations for improvement of a home-based physical activity (PA) program may help to improve engagement in virtual PA program activities. Youth voice is an often-overlooked component that may be necessary for understanding what contributes to low participation and may have important implications for long-term adherence.

Purpose: Informed by Self-Determination Theory, this study aimed to formatively evaluate home-based exercise videos, incorporating youth feedback for improvement in the development of the videos.

Applying the FRAME for Systematic Adaptation of a State Health Curriculum to Enhance Physical Activity and Family Engagement.

Background: A systematic adaptation of an evidence-based state health curriculum (Michigan Model for Health™, MMH) was created to enhance physical activity and family engagement materials but retain the core functional elements of the curriculum.

Methods: The Framework for Reporting Adaptations and Modifications-Enhanced (FRAME) was used to document the adaptation, which used materials from an evidence-informed physical activity program (Interrupting Prolonged sitting with ACTivity, InPACT). Acceptability, appropriateness, feasibility, and perceived value of the adaptation were assessed by key stakeholders, regional school health coordinators (HCs).

Optimized Enrichment of Murine Blood-Brain Barrier Vessels with a Critical Focus on Network Hierarchy in Post-Collection Analysis.

Unlabelled: Cerebrovascular networks contain a unique region of interconnected capillaries known as the blood-brain barrier (BBB). Positioned between upstream arteries and downstream veins, these microvessels have unique structural features, such as the absence of vascular smooth muscle cells (vSMCs) and a relatively thin basement membrane, to facilitate highly efficient yet selective exchange between the circulation and the brain interstitium. This vital role in neurological health and function has garnered significant attention from the scientific community and inspired methodology for enriching BBB capillaries.

Neighborhood environments underpin screen time intervention success in children: Evidence from a study of greenspace and community programming across 130 US communities.

The goal of this study was to understand how neighborhood greenspace access may support or hinder the effectiveness of community programs and policies (CPPs) aimed at reducing racial and ethnic inequities in screen time among 4598 US children. We found higher CPP intensity was significantly associated with fewer screen time behaviors in high greenspace neighborhoods, but not neighborhoods with low or moderate greenspace. Moreover, there were significant differences in greenspace access by neighborhood-level race and ethnicity.