Investigating the hypothermic effects of fluoroquinolone antimicrobials on non-bacterial fever model mice.

Background: Fluoroquinolone (FQ) antimicrobials have antipyretic effects during the treatment of bacterial infections; however, it is not clear whether these are due to their antimicrobial activities or their hypothermic effects. In this study, we investigated the hypothermic effects of FQ antimicrobials (ciprofloxacin [CPFX], gatifloxacin [GFLX], and levofloxacin [LVFX]) on fever by evaluating rectal body temperature changes in a mouse model of non-bacterial fever.

Methods: CPFX, GFLX, and LVFX were administered intraperitoneally to non-bacterial fever model mice induced by yeast.

Functional redundancy of R2R3-MYB transcription factors involved in anthocyanin biosynthesis is manifested in anther pigmentation in petunia.

Accumulation of anthocyanin provides pigmentation in plant tissues. In petunia, gene expression profiles that lead to anthocyanin production have been extensively characterized in terms of pigmentation in flower petals. Anthers are also pigmented, but the transcriptional control of the genes for anthocyanin biosynthesis in anthers has not been fully characterized.

Pre-constrain technique using the Gore Excluder Conformable endograft for abdominal aortic aneurysm with severely angulated proximal neck.

Endovascular aneurysm repair for abdominal aortic aneurysms with a severely angulated proximal neck remains challenging because of the higher rates of type 1a endoleaks and secondary interventions. In this study, we reviewed six consecutive patients with a severely angulated proximal neck (>60°) treated with endovascular aneurysm repair at a single center. They were treated with a Gore Excluder Conformable endograft using a pre-constrain technique to prevent type 1a endoleaks.