Clinician differences in attitudes and perceptions on the use of long-acting injectable antipsychotic agents in treating patients with schizophrenia: results from the US DECIDE survey.

Background: Long-acting injectable antipsychotics (LAIs) reduce relapses in schizophrenia; however, most clinicians reserve LAIs for nonadherence with oral antipsychotics (OAs) or severe disease.

Methods: US psychiatric clinicians were surveyed regarding their schizophrenia management practices and use of LAIs. Respondents were grouped by LAI use (high [≥ 31% of patients using LAIs], low [≤ 14% using LAIs]; mid not analyzed) and mindset based on their response to "Which of the following best fits the current way you view your use of [LAIs] for your patients with schizophrenia?"

Results: Respondents (n = 380) were distributed across LAI use (106 high, 130 low) and mindset (123 early-use, 88 severity-reserved, 113 adherence-reserved, 56 LAI-hesitant) subgroups.

Comparing intubation techniques of Klippel-Feil syndrome patients in the last 10 years: a systematic review.

Context: Klippel-Feil syndrome (KFS) is a rare congenital abnormality characterized by cervical vertebral fusion. Patients typically present with a triad of short neck, low posterior hairline, and limited cervical range of motion. The location and quantity of vertebral fusions in KFS makes airway management challenging in the field of anesthesia.

A comparative analysis of consumers' patterns of reimbursable prescription medications between online-only and community pharmacies.

Objectives: Online pharmacies have emerged as a novel method for procuring reimbursable medicines. The study aimed to compare consumers' patterns of reimbursable prescription medications between online-only and community pharmacies in The North Denmark Region which is one of five regions in Denmark.

Method: The retrospective study used registered data for all reimbursable medicine prescriptions from pharmacies in 2022 across Denmark but specifically retrieved from patients residing in The North Denmark Region.

Characterizing Antisense Oligonucleotide-Induced Histopathology Findings in Spinal Cord of Mauritius Cynomolgus Monkeys by Molecular Localization Investigation.

The safety of a 2'--methoxyethyl antisense oligonucleotide (ASO) was investigated in Mauritius cynomolgus monkeys in a 41-week Good Laboratory Practice (GLP) toxicity study after multiple intrathecal (IT) administrations. Histopathological examination revealed ectopic formation of lymphoid follicles in the spinal cord (SC) at the injection site at all doses and the presence of granular material in neurons of the SC in high-dose animals. The granular material was seen in all the segments of the SC, but mainly in the lumbar segment and persisted at the end of the 26-week recovery period, while the lymphoid follicles showed a reversibility trend.