Publications by authors named "R Hanif"
Article Synopsis
- * New Schiff base derivatives of amlodipine were created to evaluate their potential for inhibiting urease and their antibacterial and antioxidant properties.
- * Among the derivatives, 3g showed significant anti-hypertensive effects, while 3b, 3f, and 3g demonstrated the ability to inhibit urease, making them promising candidates for future research.
This meta-analysis has been conducted to compare the clinical outcomes between culture-positive and culture-negative sepsis or septic patients. The present meta-analysis is reported as per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Electronic databases, including PubMed and EMBASE, were searched by two authors independently from the inception to January 25, 2023, using the following key terms: "culture positive," "culture negative," "sepsis," and "septic shock.
View Article and Find Full Text PDFGold nanoparticles (AuNPs) have gained importance in the field of biomedical research and diagnostics due to their unique physicochemical properties. This study aimed to synthesize AuNPs using extract, honey, and leaf extract. Physicochemical parameters for the optimal synthesis of AuNPs were determined using 0.
View Article and Find Full Text PDFTemozolomide (TMZ), the first-line chemotherapeutic drug against glioblastoma multiforme (GBM), often fails to provide the desired clinical outcomes due to inflammation-induced resistance amid inefficient drug delivery across the blood-brain barrier (BBB). The current study utilized solid lipid nanoparticles (SLNPs) for targeted delivery of TMZ against GBM. After successful formulation and characterization of SLNPs and conjugation with TMZ (SLNP-TMZ), their in-vitro anti-cancer efficacy and effect on the migratory potential of cancer cells were evaluated using temozolomide-sensitive (U87-S) as well as TMZ-resistant (U87-R) glioma cell lines.
View Article and Find Full Text PDFBackground: Antibiotic de-escalation is a key element of antimicrobial stewardship programs that restrict the spread and emergence of resistance. This study was performed to evaluate the impact of positive culture sensitivity reports of or () on de-escalation of antibiotic therapy.
Methods: This prospective observational study was performed on 256 infected patients.