Publications by authors named "R Hanajima"
Article Synopsis
- eZIS effectively analyzes brain blood flow patterns, revealing reduced cerebral blood flow in key areas for patients with forgetfulness.
- SPECT imaging compared patients with mild cognitive impairment (MCI) and early Alzheimer's disease (AD) to controls, uncovering significant differences in blood flow.
- The study's findings highlight the left insula, operculum, and putamen as critical regions, though the broader implications for clinical treatment remain uncertain.
Article Synopsis
- A multicenter study in Japan began in 2014 to gather data on progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) to better understand their clinical features and identify potential biomarkers.
- Initial assessments of 349 patients focused on symptoms, clinical scores (like the PSPRS), and factors affecting disease progression over eight years.
- Results indicated that patients with Richardson's syndrome (RS) had better clinical scores compared to those with CBD, and cognitive dysfunction played a significant role in disease severity and progression.
Article Synopsis
- Amyotrophic lateral sclerosis (ALS) is a serious neurodegenerative disease, and recent research reveals the Src/c-Abl inhibitor, bosutinib, as a promising candidate for treatment after a phase 1 study showed it to be safe for ALS patients.
- The ongoing phase 2 study aims to assess bosutinib's efficacy and long-term safety over a 24-week treatment period, with 25 ALS patients participating and receiving either 200 mg or 300 mg doses.
- The study has ethical approval from multiple universities and plans to share its findings in peer-reviewed journals and scientific conferences.
Background: ALS is not a pure motor neuron disease but co-occurs with cognitive impairment and psychiatric symptoms. The neuropathological origin of the psychiatric symptoms is unclear. This study examined the association between the psychiatric symptoms and neuropathology of ALS.
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- - The study investigates how well conventional MRI can differentiate corticobasal degeneration (CBD) from its mimics due to similar clinical features.
- - Researchers analyzed the degree of brain atrophy and asymmetry in MRI images of 19 CBD patients and 16 patients with conditions that mimic CBD, like Alzheimer's and progressive supranuclear palsy.
- - Findings suggest that specific patterns of atrophy and the presence of white matter hyperintensity can be used as imaging biomarkers to help diagnose CBD more accurately.