Publications by authors named "R Hamby"
Spray-Induced Gene Silencing (SIGS) is an innovative and eco-friendly technology where topical application of pathogen gene-targeting RNAs to plant material can enable disease control. SIGS applications remain limited because of the instability of dsRNA, which can be rapidly degraded when exposed to various environmental conditions. Inspired by the natural mechanism of cross-kingdom RNAi through extracellular vesicle trafficking, we describe herein the use of artificial nanovesicles (AVs) for dsRNA encapsulation and control against the fungal pathogen, .
View Article and Find Full Text PDFSpray-induced gene silencing (SIGS) is an innovative and eco-friendly technology where topical application of pathogen gene-targeting RNAs to plant material can enable disease control. SIGS applications remain limited because of the instability of RNA, which can be rapidly degraded when exposed to various environmental conditions. Inspired by the natural mechanism of cross-kingdom RNAi through extracellular vesicle trafficking, we describe herein the use of artificial nanovesicles (AVs) for RNA encapsulation and control against the fungal pathogen, Botrytis cinerea.
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- Spray-induced gene silencing (SIGS) uses small RNA molecules to target and silence essential genes in fungal pathogens, thereby controlling plant diseases.
- The stability of RNA in the environment poses challenges, but using BioClay, a formulation with clay particles, can enhance the durability and effectiveness of the delivered RNA.
- Research shows that BioClay significantly extends protection against the fungal pathogen Botrytis cinerea on tomato and chickpea plants compared to standard RNA treatments, marking SIGS as a promising eco-friendly alternative to chemical fungicides.
Plants communicate with their interacting microorganisms through the exchange of functional molecules. This communication is critical for plant immunity, for pathogen virulence, and for establishing and maintaining symbioses. Extracellular vesicles (EVs) are lipid bilayer-enclosed spheres that are released by both the host and the microbe into the extracellular environment.
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