Effect of a high-impact exercise program on hip strength indices in a group of obese women after bariatric surgery.

The purpose of this study was to explore the influence of a 12-month high-impact physical training program (descending stairs) on bone health in a group of young obese women who had undergone bariatric surgery (type sleeve). Fifty-two premenopausal women with a body mass index (BMI) > 35 kg/m (range: 35.06-60.

When do science recommendations stop being effective? The case of the sprawl of diesel electricity generators in Beirut.

Lebanon, plagued by political and economic crises, experienced a government collapse in early 2020, leading to an electrical nationwide blackout by 2023. Diesel generators were used to compensate for the absence of power production from the national provider, Electricité du Liban (EDL). To investigate the effect of the crisis on the levels of 16 EPA particle bound polycyclic aromatic hydrocarbons (PPAHs), an annual comparative analysis of three locations within Beirut started in 2022 and ended in 2023.

Seroprevalence and factors associated with exposure to among dairy cattle smallholders in southern Rio Grande do Sul.

is a protozoan parasite that infects several species of animals (domestic and wild) and is one of the most common causes of abortion in cattle worldwide. To better understand the epidemiological chain of neosporosis, update the disease status and propose control measures to improve milk production in Rio Grande do Sul (RS), the present study aimed to evaluate the seroprevalence of and its distribution in different municipalities of Rio Grande do Sul, Southern RS, Brazil, and determine the factors associated with exposure to in small dairy cattle producers in this region. Cattle from 51 dairy farms located in nine municipalities in the southern region of RS were included in this study.

Five-Year Outcomes of Lenadogene Nolparvovec Gene Therapy in Leber Hereditary Optic Neuropathy.

Importance: Limited studies have assessed the long-term benefit/risk of gene therapy for Leber hereditary optic neuropathy (LHON).

Objective: To determine the safety and efficacy of lenadogene nolparvovec in patients with LHON due to the MT-ND4 gene variant for up to 5 years after administration.

Design, Setting, And Participants: The RESCUE and REVERSE Long-Term Follow-up Study (RESTORE), conducted from 2018 to 2022, is the 5-year follow-up study of the 2 phase 3 clinical studies RESCUE (Efficacy Study of Lenadogene Nolparvovec for the Treatment of Vision Loss Up to 6 Months From Onset in LHON Due to the MT-ND4 Mutation) and REVERSE (Efficacy Study of Lenadogene Nolparvovec for the Treatment of Vision Loss From 7 Months to 1 Year From Onset in LHON Due to the MT-ND4 Mutation).

Combined pulmonary fibrosis and emphysema and lung transplantation: current evidence and future directions.

Background: Combined pulmonary fibrosis and emphysema (CPFE) patients generally have a poorer prognosis compared to those with either pulmonary fibrosis or chronic obstructive pulmonary disease (COPD)/emphysema alone, as demonstrated by several studies. Our study aimed to identify undiagnosed CPFE cases within a lung transplantation cohort initially diagnosed with interstitial lung fibrosis or COPD/emphysema. It was hypothesized that the patient cohort might contain overlooked CPFE cases, and CPFE patients would exhibit a higher incidence of pre-transplant pulmonary hypertension and post-transplant chronic lung allograft dysfunction (CLAD).