Publications by authors named "R Hachem"
The Specialized Donor Care Facility Model Improves Operating Room Efficiency.
Ann Thorac Surg Short Rep
September 2024
Background: Organ procurement organizations coordinate organ donation through 2 distinct models of care: the conventional model, in which donors are managed at hospitals where brain death occurs, and the specialized donor care facility (SDCF) model, where brain dead donors are transferred to a freestanding facility. The aim of this study is to compare operating room efficiency for procurements between the SDCF and conventional models of care.
Methods: We performed a prospective analysis of operating room efficiency between thoracic donor procurement operations performed at a SDCF and other organ procurement organizations using the conventional model of care.
Objectives: The aim of this study was to determine the effect of apical preparation size and preparation taper on smear layer removal using a metallic needle and a new polymer needle (IrriFlex, Produits Dentaires SA "PD," Vevey, Switzerland).
Materials And Methods: One hundred and eight single-rooted teeth with one canal were randomly divided into four groups according to the preparation and irrigation needle used: G1-30, 0.04 and IrriFlex ( = 25); G2-25, 0.
There is a paucity of data reporting the positive and negative predictive values (PPV, NPV) of acute declines in lung function on chronic lung allograft dysfunction (CLAD). We sought to define the predictive ability of single or repeated forced expiratory volume in the first second (FEV) declines for at least 3 weeks on the development of CLAD or death by 1-year. We analyzed 340 subjects with at least 3 years of follow-up data from two lung transplant centers.
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- A better understanding of chronic lung allograft dysfunction (CLAD) is needed, as it leads to high mortality rates after lung transplants.
- The study focused on a genetic variation (C3R102G) that enhances complement activation, finding that lung transplant recipients with this variation tend to have poorer outcomes related to CLAD, especially if they develop donor-specific antibodies.
- In experiments with mice, decreased regulation of the complement system resulted in worse airway damage and increased B cell activity, linking genetic predisposition to complement activation with worse survival outcomes after lung transplantation.
Article Synopsis
- - Induction immunosuppression in solid organ transplants aims to prevent early rejection and reduce kidney injury by using strong immunosuppressive drugs during the perioperative period.
- - In lung transplants, over 80% of adult recipients now receive induction therapy, predominantly using interleukin-2 receptor antagonists like basiliximab.
- - Despite its growing use, there is limited evidence guiding the practice of induction immunosuppression in lung transplantation, leading to ongoing debates about its effectiveness.