Cycle-Based Control of Injection Moulding Process in Presence of Material Dual Sourcing Using Mass Feedback.

The low cost and precise tolerances of plastic injection moulded products are a major reason for the popularity of the manufacturing method. The tolerances are greatly influenced by the equipment, raw material and moulding process. One challenge is the raw material variation.

Development and Validation of a 1D Dynamic Model of an Injection Moulding Process and Design of a Model-Based Nozzle Pressure Controller.

A 1D model describing the dynamics of an injection moulding machine and the injection process is presented. The model describes an injection cylinder actuated by a dual-pump electro-hydraulic speed-variable drive and the filling, holding and cooling phases of the injection moulding process utilising amorphous polymers. The model is suggested as the foundation for the design of model-based pressure controllers of, e.

Amyloidogenic light chains impair plasma cell survival.

Systemic light chain amyloidosis (AL) is a clonal plasma cell disorder characterized by the deposition of misfolded immunoglobulin light chains (LC) as insoluble fibrils in organs. The lack of suitable models has hindered the investigation of the disease mechanisms. Our aim was to establish AL LC-producing plasma cell lines and use them to investigate the biology of the amyloidogenic clone.

Sociological Accounts of Donor Siblings' Experiences: Their Importance for Self-Identity and New Kinship Relations.

A fundamental part of the adolescent self is formed through interaction with intimates, usually family members whose roles are reasonably well-defined. However, donor siblings-children who share a sperm donor-lack social scripts for interacting with one another, particularly when they are raised in different households. Moreover, they are often challenged to figure out their relationship to newly discovered genetic relatives.

Suppression of multiple myeloma by mitochondrial targeting.

Treatment of multiple myeloma (MM) aims at inducing cell apoptosis by surpassing the limited capacity of MM cells to cope with oxidative stress. MM cell survival may further be suppressed by limiting cellular cholesterol. Long-chain fatty acid analogs of the MEDICA series promote mitochondrial stress and inhibit cholesterol biosynthesis, thus prompting us to verify their efficacy and mode-of-action in suppressing MM cell survival, in comparison to bortezomib.