Publications by authors named "R H. Getzenberg"
Article Synopsis
- Solid tumors, leukemias, and lymphomas exhibit significant changes in nuclear structure, which are important for cancer diagnosis and may impact how cancer cells function.
- The nuclear matrix (NM) is essential for the nucleus's structure and interacts with various protein complexes that influence gene activity and DNA organization, potentially contributing to cancer progression.
- Research on LNCaP and LN96 prostate cancer cell lines shows that purine-rich element binding protein alpha (PURα) is a key NM protein that differs between the two cell lines, suggesting it may play a significant role in prostate cancer.
Introduction: The availability of oral therapies for advanced prostate cancer allows urologists to continue to care for their patients who develop castration resistance. We compared the prescribing practices of urologists and medical oncologists in treating this patient population.
Methods: The Medicare Part D Prescribers data sets were utilized to identify urologists and medical oncologists who prescribed enzalutamide and/or abiraterone from 2013 to 2019.
Purpose: Sabizabulin, an oral cytoskeleton disruptor, was tested in a phase Ib/II clinical study in men with metastatic castration-resistant prostate cancer (mCRPC).
Patients And Methods: The phase Ib portion utilized a 3+3 design with escalating daily oral doses of 4.5-81 mg and increasing schedule in 39 patients with mCRPC treated with one or more androgen receptor-targeting agents.
We performed a retrospective study to determine the epidemiology of Rothia mucilaginosa infections among pediatric cancer patients. Over 20 years, 37 cases were identified; 27% developed complications, but there was no infection-related mortality. All cases were successfully treated with vancomycin.
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