Dystonia caused by ANO3 variants is due to attenuated Ca influx by ORAI1.

Background: Dystonia is a common neurological hyperkinetic movement disorder that can be caused by mutations in anoctamin 3 (ANO3, TMEM16C), a phospholipid scramblase and ion channel. We previously reported patients that were heterozygous for the ANO3 variants S651N, V561L, A599D and S651N, which cause dystonia by unknown mechanisms.

Methods: We applied electrophysiology, Ca measurements and cell biological methods to analyze the molecular mechanisms that lead to aberrant intracellular Ca signals and defective activation of K channels in patients heterozygous for the ANO3 variants.

Prediction of severity of obstructive sleep apnea by awake impulse oscillometry.

Objective/background: Obstructive sleep apnea (OSA) is a common disease, which poses a significant health threat. Initial diagnostics with polygraphy or polysomnography are time consuming and expensive. Therefore, there is an unmet medical need for simplification, especially to exclude healthy patients from elaborate and unnecessary diagnostics.

What goals do people have for who they want to be emotionally? Exploring long-term emotional goals.

The goals that people have for their emotions are crucial for whether emotion regulation is pursued, as well as the regulation strategies people select. However, emotional goals may extend beyond the emotions people want to feel to include long-term goals for how people want to be emotionally in the future. In two studies, we qualitatively explored people's long-term emotional goals (i.

Revision of the Aspistomella group of genera (Diptera: Ulidiidae: Pterocallinae: Lipsanini).

Twenty-three species of the genera Aspistomella Hendel, 1909, Polyteloptera Hendel, 1909, and Ulivellia Speiser, 1929 occurring in South America (Colombia, Peru, Bolivia, and Brazil) form a monophyletic lineage sharing certain combinations of plesiomorphies and apomorphies with similar larval biology. The name Aspistomella Hendel, 1909 is a new senior subjective synonym of Paraphyola Hendel, 1909. The group of genera is extended by the addition of six known species, Aspistomella angustifrons (Hendel, 1909) comb.

The dual GLP-1/glucagon receptor agonist G49 mimics bariatric surgery effects by inducing metabolic rewiring and inter-organ crosstalk.

Bariatric surgery is effective for the treatment and remission of obesity and type 2 diabetes, but pharmacological approaches which exert similar metabolic adaptations are needed to avoid post-surgical complications. Here we show how G49, an oxyntomodulin (OXM) analog and dual glucagon/glucagon-like peptide-1 receptor (GCGR/GLP-1R) agonist, triggers an inter-organ crosstalk between adipose tissue, pancreas, and liver which is initiated by a rapid release of free fatty acids (FFAs) by white adipose tissue (WAT) in a GCGR-dependent manner. This interactome leads to elevations in adiponectin and fibroblast growth factor 21 (FGF21), causing WAT beiging, brown adipose tissue (BAT) activation, increased energy expenditure (EE) and weight loss.