Publications by authors named "R H Megens"
Article Synopsis
- CCL17, produced by conventional dendritic cells, negatively affects regulatory T cells (Tregs) and contributes to atherosclerosis by suppressing Treg functions, but the exact mechanisms are still unclear.
- Research on CCL17-deficient mice shows a different immune response that doesn't occur in mice lacking the CCR4 receptor, revealing a potential alternate signaling pathway involving CCR8 and CCL3.
- The study finds that levels of CCL3 are linked to Treg activity and atherosclerosis severity, with increased CCL3 associated with disease progression, indicating a complex interaction that may impact therapeutic strategies.
The human bone marrow (BM) niche sustains hematopoiesis throughout life. We present a method for generating complex BM-like organoids (BMOs) from human induced pluripotent stem cells (iPSCs). BMOs consist of key cell types that self-organize into spatially defined three-dimensional structures mimicking cellular, structural and molecular characteristics of the hematopoietic microenvironment.
View Article and Find Full Text PDFThe CXC chemokine receptor 4 (CXCR4) in endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) is crucial for vascular integrity. The atheroprotective functions of CXCR4 in vascular cells may be counteracted by atherogenic functions in other nonvascular cell types. Thus, strategies for cell-specifically augmenting CXCR4 function in vascular cells are crucial if this receptor is to be useful as a therapeutic target in treating atherosclerosis and other vascular disorders.
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