Publications by authors named "R H Hawes"
Background: Primary luminal breast cancer cells lose their identity rapidly in standard tissue culture, which is problematic for testing hormone interventions and molecular pathways specific to the luminal subtype. Breast cancer organoids are thought to retain tumor characteristics better, but long-term viability of luminal-subtype cases is a persistent challenge. Our goal was to adapt short-term organoids of luminal breast cancer for parallel testing of genetic and pharmacologic perturbations.
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- - The study investigates the effectiveness of endoscopic ultrasound (EUS)-guided celiac plexus block versus a sham procedure in alleviating abdominal pain for patients suffering from chronic pancreatitis, with the aim of determining pain reduction statistics.
- - Conducted as a randomized sham-controlled trial, the research will involve multiple academic sites and focus on patients whose chronic pancreatitis is confirmed by EUS diagnostic criteria, measuring outcomes like pain reduction through specific pain assessment tools.
- - The ultimate goal is to provide a clear evaluation of celiac plexus block’s efficacy compared to a placebo treatment, which may help in managing chronic pain related to pancreatitis more effectively.
Background: Primary luminal breast cancer cells lose their identity rapidly in standard tissue culture, which is problematic for testing hormone interventions and molecular pathways specific to the luminal subtype. Breast cancer organoids are thought to retain tumor characteristics better, but long-term viability of luminal-subtype cases is a persistent challenge. Our goal was to adapt short-term organoids of luminal breast cancer for parallel testing of genetic and pharmacologic perturbations.
View Article and Find Full Text PDFBackground: Standard linear echoendoscopes have a large distal tip and bending radius, which can preclude adequate examination in some patients.
Objective: We examined the impact of having available slim linear echoendoscopes (SLE) on our endoscopic ultrasound (EUS) practice.
Materials And Methods: As a quality improvement measure, data on the need for the use of SLE were documented in 2000 consecutive procedures performed over a 10-month period from February to November 2022.